Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 67,450 bioRxiv papers from 297,377 authors.

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

By Leehee Weinberger, Muneef Ayyash, Noa Novershtern, Jacob H Hanna

Posted 06 Nov 2015
bioRxiv DOI: 10.1101/030676 (published DOI: 10.1038/nrm.2015.28)

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of distinct pluripotent stem cell configurations, and their induction in somatic cells via direct reprogramming approaches, continue to constitute a highly exciting area of research. In this review, we provide an integrative synthesis on recent discoveries related to isolating unique naive and primed pluripotent stem cell states with altered functional and molecular characteristics, and from different species. We overview pathways underlying pluripotent state transitions and interconversion in vitro and in vivo. We conclude by highlighting unresolved key questions, future directions and potential novel applications of such dynamic pluripotent cell states.

Download data

  • Downloaded 4,113 times
  • Download rankings, all-time:
    • Site-wide: 650 out of 67,459
    • In developmental biology: 10 out of 2,005
  • Year to date:
    • Site-wide: 3,705 out of 67,459
  • Since beginning of last month:
    • Site-wide: 7,971 out of 67,459

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News