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Dynamic stem cell states: naive to primed pluripotency in rodents and humans

By Leehee Weinberger, Muneef Ayyash, Noa Novershtern, Jacob H. Hanna

Posted 06 Nov 2015
bioRxiv DOI: 10.1101/030676 (published DOI: 10.1038/nrm.2015.28)

The molecular mechanisms and signalling pathways that regulate the in vitro preservation of distinct pluripotent stem cell configurations, and their induction in somatic cells via direct reprogramming approaches, continue to constitute a highly exciting area of research. In this review, we provide an integrative synthesis on recent discoveries related to isolating unique naive and primed pluripotent stem cell states with altered functional and molecular characteristics, and from different species. We overview pathways underlying pluripotent state transitions and interconversion in vitro and in vivo. We conclude by highlighting unresolved key questions, future directions and potential novel applications of such dynamic pluripotent cell states.

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