The Drosophila Neurogenin, Tap, controls axonal growth through the Wnt adaptor protein Dishevelled
Natalie De Geest,
Bassem A Hassan,
Posted 15 Dec 2015
bioRxiv DOI: 10.1101/034439 (published DOI: 10.1242/dev.134155)
Posted 15 Dec 2015
The Neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, their function in neurite growth is poorly understood. Drosophila has a single predicted Ngn homologue called Tap, whose function is completely unknown. Here we show that Tap is not a proneural protein in Drosophila but is required for proper axonal growth and guidance of neurons of the mushroom body (MB), a neuropile required for associative learning and memory. Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein, Dishevelled.
- Downloaded 361 times
- Download rankings, all-time:
- Site-wide: 46,800 out of 92,758
- In developmental biology: 1,400 out of 2,752
- Year to date:
- Site-wide: 88,244 out of 92,758
- Since beginning of last month:
- Site-wide: 66,394 out of 92,758
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!