Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,170 bioRxiv papers from 306,408 authors.

Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth

By Alberto Rosello-Diez, Linda Madisen, S├ębastien Bastide, Hongkui Zeng, Alexandra L. Joyner

Posted 23 Dec 2017
bioRxiv DOI: 10.1101/218487 (published DOI: 10.1371/journal.pbio.2005086)

Catch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, local injury is followed by local and systemic compensatory mechanisms that allow damaged tissues to regain proportions with other tissues. In vertebrates, local catch-up growth has been described after transient reduction of bone growth, but the underlying cellular responses are controversial. We developed an approach to study catch-up growth in foetal mice by inducing mosaic expression of the cell cycle suppressor p21 in the cartilage cells (chondrocytes) that drive long bone elongation. By specifically targeting the left hindlimb, the right limb served as an internal control. Strikingly, left-right limb symmetry was not altered, revealing deployment of compensatory mechanisms. Above a certain threshold of insult, an orchestrated response was triggered involving local enhancement of bone growth and systemic growth reduction that ensured body proportions were maintained. The local response entailed hyper-proliferation of spared left-limb chondrocytes that was associated with reduced chondrocyte density. The systemic effect involved impaired placental IGF signalling and function, revealing bone-placenta communication. Thus, vertebrates can mount coordinated local and systemic responses to developmental insults to ensure normal body proportions are maintained.

Download data

  • Downloaded 352 times
  • Download rankings, all-time:
    • Site-wide: 33,167 out of 70,177
    • In developmental biology: 962 out of 2,098
  • Year to date:
    • Site-wide: 53,780 out of 70,177
  • Since beginning of last month:
    • Site-wide: 56,533 out of 70,177

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News