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TumorFusions: an integrative resource for reporting cancer-associated transcript fusions in 33 tumor types

By Xin Hu, Qianghu Wang, Floris Barthel, Ming Tang, Samirkumar Amin, Kosuke Yoshihara, Frederick M. Lang, Soo Hyun Lee, Siyuan Zheng, Roel G.W. Verhaak

Posted 11 Jul 2017
bioRxiv DOI: 10.1101/162180 (published DOI: 10.1093/nar/gkx1018)

We have comprehensively determined the presence of somatic transcript fusions in cancer. To do so, we analyzed RNAseq files across 33 tumor types, totaling 9,966 cancer samples and 648 non-neoplastic samples, accessible through The Cancer Genome Atlas. To validate the resultant fusions, we called somatic structural variations for 561 cancers from whole genome sequencing data. Our results can be accessed per our portal at http://www.tumorfusions.org.

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