Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,351 bioRxiv papers from 289,484 authors.
Portraits of genetic intra-tumour heterogeneity and subclonal selection across cancer types
Stefan C. Dentro,
Dimitri G. Livitz,
Steven E Schumacher,
Ruben M. Drews,
David J. Adams,
Paul C. Boutros,
S. Cenk Sahinalp,
Paul T. Spellman,
Quaid D Morris,
David C. Wedge,
Peter Van Loo
Posted 05 May 2018
bioRxiv DOI: 10.1101/312041
Posted 05 May 2018
Continued evolution in cancers gives rise to intra-tumour heterogeneity (ITH), which is a major mechanism of therapeutic resistance and therefore an important clinical challenge. However, the extent, origin and drivers of ITH across cancer types are poorly understood. Here, we extensively characterise ITH across 2,778 cancer whole genome sequences from 36 cancer types. We demonstrate that nearly all tumours (95.1%) with sufficient sequencing depth contain evidence of recent subclonal expansions and most cancer types show clear signs of positive selection in both clonal and subclonal protein coding variants. We find distinctive subclonal patterns of driver gene mutations, fusions, structural variation and copy-number alterations across cancer types. Dynamic, tumour-type specific changes of mutational processes between subclonal expansions shape differences between clonal and subclonal events. Our results underline the importance of ITH and its drivers in tumour evolution and provide an unprecedented pan-cancer resource of extensively annotated subclonal events, laying a foundation for future cancer genomic studies.
- Downloaded 3,888 times
- Download rankings, all-time:
- Site-wide: 699 out of 65,351
- In cancer biology: 21 out of 2,179
- Year to date:
- Site-wide: 1,131 out of 65,351
- Since beginning of last month:
- Site-wide: 2,280 out of 65,351
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!