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The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens.

By Dimitra Repana, Joel Nulsen, Lisa Dressler, Michele Bortolomeazzi, Santhilata Kuppili Venkata, Aikaterini Tourna, Anna Yakovleva, Tommaso Palmieri, Francesca D. Ciccarelli

Posted 11 Aug 2018
bioRxiv DOI: 10.1101/389858 (published DOI: 10.1186/s13059-018-1612-0)

The Network of Cancer Genes (NCG) is a manually curated repository of 2,372 genes whose somatic modification is known or predicted to have a cancer driver role. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of 119 cancer types in 31 primary sites, for a total of 34,905 cancer donors. In addition to collecting cancer genes, NCG annotates their systems-level properties, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, protein function and essentiality. NCG offers a comprehensive and up-to-date collection of cancer genes and is accessible at http://ncg.kcl.ac.uk/.

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