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Highly Multiplexed Single-Cell RNA-seq for Defining Cell Population and Transcriptional Spaces

By Jase Gehring, Jong Hwee Park, Sisi Chen, Matthew Thomson, Lior Pachter

Posted 05 May 2018
bioRxiv DOI: 10.1101/315333

We describe a universal sample multiplexing method for single-cell RNA-seq in which cells are chemically labeled with identifying DNA oligonucleotides. Analysis of a 96-plex perturbation experiment revealed changes in cell population structure and transcriptional states that cannot be discerned from bulk measurements, establishing a cost effective means to survey cell populations from large experiments and clinical samples with the depth and resolution of single-cell RNA-seq.

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