REM Sleep Movements in Parkinson's Disease: Is the Basal Ganglia Engaged?
Ajay K Verma,
Sergio F Acosta Lenis,
Joshua E Aman,
David Escobar Sanabria,
Lauren E Schrock,
Scott E Cooper,
Michael C Park,
Michael J Howell,
Colum D MacKinnon,
Jerrold L Vitek,
Luke A Johnson
Posted 28 May 2022
bioRxiv DOI: 10.1101/2022.05.25.493494
Posted 28 May 2022
To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.
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