Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages
By
Amirhossein Modabbernia,
Didac Vidal-Pineiro,
Ingrid Agartz,
Ole Andreassen,
Rosa Ayesa-Arriola,
Alessandro Bertolino,
Dorret Boomsma,
Josiane Bourque,
Alan Breier,
Rachel M Brouwer,
Jan Buitelaar,
Erick J Canales-Rodriguez,
Xavier Caseras,
Patricia J Conrod,
Benedicto Crespo-Facorro,
Fabrice Crivello,
Eveline A Crone,
Greig I de Zubicaray,
Erin W Dickie,
Danai Dima,
Stefan Frenzel,
Simon E. Fisher,
Barbara Franke,
David C Glahn,
Hans-Jorgen Grabe,
Dominik Grotegerd,
Oliver Gruber,
Amalia Guerrero-Pedraza,
Raquel E Gur,
Ruben C Gur,
Catharina A Hartman,
Pieter J Hoekstra,
Hilleke E. Hulshoff Pol,
Neda Jahanshad,
Terry L Jernigan,
Jiyang Jiang,
Andrew J Kalnin,
Nicole A Kochan,
Bernard Mazoyer,
Brenna C McDonald,
Katie L McMahon,
Lars Nyberg,
Jaap Oosterlaan,
Edith Pomarol-Clotet,
Joaquim Radua,
Perminder S. Sachdev,
Theodore D Satterthwaite,
Raymond Salvador,
Salvador Sarro,
Saykin J Andrew,
Gunter Schumann,
Jordan W Smoller,
Iris E Sommer,
Thomas Espeseth,
Sophia I Thomopoulos,
Julian N Trollor,
Dennis van 't Ent,
Aristotle Voineskos,
Yang Wang,
Bernd Weber,
Wei Wen,
Lars T. Westlye,
Heather C Whalley,
Steven Williams,
Katharina Wittfeld,
Margaret J Wright,
Paul M Thompson,
Thomas Paus,
Sophia Frangou
Posted 22 Mar 2022
bioRxiv DOI: 10.1101/2022.03.21.484899
Mechanisms underpinning age-related variations in cortical thickness in the human brain remain poorly understood. We investigated whether inter-regional age-related variations in cortical thinning (in a multicohort neuroimaging dataset from the ENIGMA Lifespan Working Group totalling 14,248 individuals, aged 4-89 years) depended on cell-specific marker gene expression levels. We found differences amidst early-life (<20 years), mid-life (20-60 years), and late-life (>60 years) in the patterns of association between inter-regional profiles of cortical thickness and expression profiles of marker genes for CA1 and S1 pyramidal cells, astrocytes, and microglia. Gene ontology and enrichment analyses indicated that each of the three life-stages was associated with different biological processes and cellular components: synaptic modeling in early life, neurotransmission in mid-life, and neurodegeneration in late-life. These findings provide mechanistic insights into age-related cortical thinning during typical development and aging.
Download data
- Downloaded 199 times
- Download rankings, all-time:
- Site-wide: 166,712
- In neuroscience: None
- Year to date:
- Site-wide: 19,529
- Since beginning of last month:
- Site-wide: 30,442
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!