Large Meta-Analysis in the CHARGE Consortium Provides Evidence For an Association of Serum Vitamin D With Pulmonary Function
By
Jiayi Xu,
Traci M Bartz,
Geetha Chittoor,
Gudny Eiriksdottir,
Ani W. Manichaikul,
Fangui Sun,
Natalie Terzikhan,
Xia Zhou,
Sarah L. Booth,
Guy G. Brusselle,
Ian H. de Boer,
Myriam Fornage,
Alexis C. Frazier-Wood,
Mariaelisa Graff,
Vilmundur Gudnason,
Tamara B. Harris,
Albert Hofman,
Ruixue Hou,
Denise K. Houston,
David R. Jacobs,
Stephen B. Kritchevsky,
Jeanne Latourelle,
Rozenn N. Lemaitre,
Pamela L Lutsey,
George O’Connor,
Elizabeth C. Oelsner,
James S Pankow,
Bruce M Psaty,
Rebecca R. Rohde,
Stephen S Rich,
Jerome I. Rotter,
Lewis J. Smith,
Bruno H. Stricker,
V. Saroja Voruganti,
Thomas J. Wang,
M. Carola Zillikens,
R. Graham Barr,
Josée Dupuis,
Sina A Gharib,
Lies Lahousse,
Stephanie London,
Kari E. North,
Albert V Smith,
Lyn M. Steffen,
Dana B Hancock,
Patricia A. Cassano
Posted 02 Jun 2017
bioRxiv DOI: 10.1101/144717
The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for the association of serum 25-hydroxyvitamin D [25(OH)D] and pulmonary function. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n=22,838) and five African ancestry (AA) cohorts (n=4,290) in the CHARGE Consortium. Data were analyzed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean (SD) serum 25(OH)D was 68 (29) nmol/L for EAs and 49 (21) nmol/L for AAs. For each 1 nmol/L higher 25(OH)D, forced expiratory volume in the first second (FEV1) was higher by 1.1 mL in EAs (95% CI: 0.9,1.3; P=2.5×10-21) and 1.8 mL (95% CI: 1.1,2.5; P=1.6×10-7) in AAs (Prace difference=0.06), and forced vital capacity (FVC) was higher by 1.3 mL in EAs (95% CI: 1.0,1.6; P=1.1×10-20) and 1.5 mL (95% CI: 0.8,2.3; P=1.2×10-4) in AAs (Prace difference=0.56). Among EAs, the 25(OH)D-FVC association was stronger in smokers: per 1nmol/L higher 25(OH)D, FVC was higher by 1.7 mL (95% CI: 1.1,2.3) for current smokers and 1.7 mL (95% CI: 1.2,2.1) for former smokers, compared to 0.8 mL (95% CI: 0.4,1.2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EAs, a stronger association was observed for smokers compared to never smokers, which supports the importance of vitamin D in vulnerable populations.
Download data
- Downloaded 433 times
- Download rankings, all-time:
- Site-wide: 58,164
- In epidemiology: 2,487
- Year to date:
- Site-wide: 93,645
- Since beginning of last month:
- Site-wide: 94,938
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!