Low back pain is mostly caused by disc degeneration, which is due to the alterations in the osmotic pressure of nucleus pulposus cells. However, the knowledge about the mechanism and therapies for disc degeneration is not fully understood. Here, our objective is to identify significantly changed genes and biological processes in the stretched nucleus pulposus cells. The GSE175710 dataset was originally produced by using the Illumina HiSeq 4000 (Rattus norvegicus). The KEGG and GO analyses indicated that MAPK signaling, TNF signaling, IL17 signaling, and the NF-kB signaling pathway are mostly affected in the stretched nucleus pulposus cells. Moreover, we identified several genes according to the PPI network such as Mmp9, Cxcl12, Col1a1, and Col3a1 in the stretched nucleus pulposus cells. Thus, our study provides further insights into the study of disc deterioration.
- Downloaded 89 times
- Download rankings, all-time:
- Site-wide: 202,325
- In bioinformatics: 14,159
- Year to date:
- Site-wide: 175,147
- Since beginning of last month:
- Site-wide: 199,976
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!