Oxytocin enhances intrinsic corticostriatal functional connectivity in women
Richard A.I. Bethlehem,
Michael V. Lombardo,
Sarah K. Crockford,
Posted 09 Aug 2016
bioRxiv DOI: 10.1101/068585 (published DOI: 10.1038/tp.2017.72)
Posted 09 Aug 2016
Background: Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male-biased and often constrained by task-based inferences. Here we investigate the impact of oxytocin on resting state connectivity between subcortical and cortical networks women. Methods: We collected resting state fMRI data on 26 typically-developing women following intranasal oxytocin administration using a double-blind placebo-controlled crossover design. Independent components analysis (ICA) was applied to examine connectivity between networks. An independent analysis of oxytocin receptor (OXTR) gene expression in human subcortical and cortical areas was carried out to determine plausibility of direct oxytocin effects on OXTR. Results: In women, OXTR was highly expressed in striatal and other subcortical regions, but showed modest expression in cortical areas. Oxytocin increased connectivity between corticostriatal circuitry typically involved in reward, emotion, social-communication, language, and pain processing. This effect was 1.39 standard deviations above the null effect of no difference between oxytocin and placebo. This oxytocin-related effect on corticostriatal connectivity covaried with autistic traits, such that oxytocin-related increase in connectivity was stronger in individuals with higher autistic traits. Discussion: Oxytocin strengthens corticostriatal connectivity in women, particularly with cortical networks that are involved in social-communicative, motivational, and affective processes. This effect may be important for future work on neurological and psychiatric conditions (e.g., autism, chronic pain), particularly through highlighting how oxytocin may operate differently for subsets of individuals.
- Downloaded 830 times
- Download rankings, all-time:
- Site-wide: 23,852
- In neuroscience: 3,182
- Year to date:
- Site-wide: None
- Since beginning of last month:
- Site-wide: 106,712
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!