Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,568 bioRxiv papers from 290,397 authors.
A Complete Electron Microscopy Volume Of The Brain Of Adult Drosophila melanogaster
J. Scott Lauritzen,
Camenzind G. Robinson,
Corey B. Fisher,
Steven A. Calle-Schuler,
Iqbal J. Ali,
Eric T. Trautman,
Gregory S. X. E. Jefferis,
Richard D. Fetter,
Davi D. Bock
Posted 22 May 2017
bioRxiv DOI: 10.1101/140905 (published DOI: 10.1016/j.cell.2018.06.019)
Posted 22 May 2017
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only electron microscopy (EM) enables complete, unbiased mapping of synaptic connectivity; however, the fly brain is too large for conventional EM. We developed a custom high-throughput EM platform and imaged the entire brain of an adult female fly. We validated the dataset by tracing brain-spanning circuitry involving the mushroom body (MB), intensively studied for its role in learning. Here we describe the complete set of olfactory inputs to the MB; find a new cell type providing driving input to Kenyon cells (the intrinsic MB neurons); identify neurons postsynaptic to Kenyon cell dendrites; and find that axonal arbors providing input to the MB calyx are more tightly clustered than previously indicated by light-level data. This freely available EM dataset will significantly accelerate Drosophila neuroscience.
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