Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,446 bioRxiv papers from 307,622 authors.
Conservation of differentiation but transformation of initiation in hippocampal neurogenesis
The dentate gyrus in the hippocampal formation is one of few regions in the brain where neurogenesis persists in the adult, and is therefore studied in the context of neurodevelopment and regenerative medicine. However, the relationship between developmental and adult neurogenesis has not been studied in detail. Here, we used extensive and unbiased single-cell RNA-seq to reveal the molecular dynamics and diversity of cell types in perinatal, juvenile and adult mice. We found clearly distinct quiescent and proliferating progenitor cell types, linked by transient intermediate states to neuroblast stages and fully mature granule cells. The molecular identity of quiescent and proliferating radial glia shifted after postnatal day 5, and was then maintained through postnatal and adult stages. A similar shift was observed for granule cells at P20. In contrast, intermediate progenitor cells, neuroblasts and immature granule cells were nearly indistinguishable at all ages. These findings demonstrate the fundamental continunity of postnatal and adult neurogenesis in the hippocampus, and pinpoint the early postnatal transformation of radial glia from embryonic progenitors to adult quiescent stem cells.
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