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Brain charts for the human lifespan

By Richard A. I. Bethlehem, Jakob Seidlitz, Simon R. White, Jacob W. Vogel, Kevin M. Anderson, Chris Adamson, Sophie Adler, George S. Alexopoulos, Evdokia Anagnostou, Ariosky Areces-Gonzalez, Duncan Astle, Bonnie Auyeung, Muhammad Ayub, Gareth Ball, Simon Baron-Cohen, Richard Beare, Saashi A. Bedford, Vivek Benegal, Frauke Beyer, Jong Bin Bae, John Blangero, Manuel Blesa Cabez, James P. Boardman, Matthew Borzage, Jorge F. Bosch-Bayard, Niall Bourke, Vince Calhoun, Mallar Chakravarty, Christina Chen, Casey Chertavian, Gael Chetelat, Yap S. Chong, James H Cole, Aiden Corvin, Manuela Costantino, Eric Courchesne, Fabrice Crivello, Vanessa L. Cropley, Jennifer Crosbie, Nicolas Crossley, Marion Delarue, Richard Delorme, Sylvane Desrivieres, Gabriel Devenyi, Maria A. Di Biase, Ray Dolan, Kirsten A. Donald, Gary Donohoe, Katharine Dunlop, A David Edwards, Jed T. Elison, Cameron T. Ellis, Jeremy A. Elman, Lisa Eyler, Damien A. Fair, Eric Feczko, Paul C. Fletcher, Peter Fonagy, Carol E. Franz, Lidice Galan-Garcia, Ali Gholipour, Jay Giedd, John H. Gilmore, David C Glahn, Ian Goodyer, P. E. Grant, Nynke A. Groenewold, Faith M. Gunning, Raquel E. Gur, Ruben C Gur, Christopher F. Hammill, Oskar Hansson, Trey Hedden, Andreas Heinz, Richard N Henson, Katja Heuer, Jacqueline Hoare, Bharath Holla, Avram Holmes, Rosie Holt, Hao Huang, Kiho Im, Jonathan Ipser, Clifford R. Jack, Andrea P. Jackowski, Tianye Jia, Keith A. Johnson, David T. Jones, Peter B. Jones, Rene Kahn, Hasse Karlsson, Linnea Karlsson, Ryuta Kawashima, Elizabeth A. Kelley, Silke Kern, K.W. Kim, Manfred G. Kitzbichler, William S. Kremen, Francois Lalonde, Brigitte Landeau, Subin Lee, Jason Lerch, John D. Lewis, Jiao Li, Wei Liao, Deirel P. Linares, Conor Liston, Michael V. Lombardo, Jinglei Lv, Charles Lynch, Travis T Mallard, Machteld Marcelis, Samuel R Mathias, Ross D Markello, Bernard Mazoyer, Philip McGuire, Michael Meaney, Andrea Mechelli, Nenad Medic, Bratislav Misic, Sarah E Morgan, David Mothersill, Joel Nigg, Marcus Q.W. Ong, Cynthia Ortinau, Rik Ossenkoppele, Minhui Ouyang, Lena Palaniyappan, Leo Paly, Pedro M. Pan, Christos Pantelis, Min Tae M. Park, Tomas Paus, Zdenka Pausova, Alexa Pichet Binette, Karen Pierce, Xing Qian, Anqi Qiu, Jiang Qiu, Armin Raznahan, Timothy Rittman, Amanda Rodrigue, Caitlin K. Rollins, Rafael Romero-Garcia, Lisa Ronan, Monica D. Rosenberg, David H. Rowitch, Giovanni A. Salum, Theodore D Satterthwaite, H. Lina Schaare, Russell J Schachar, Michael Scholl, Aaron P. Schultz, Gunter Schumann, David Sharp, Russell T Shinohara, Ingmar Skoog, Christopher D. Smyser, Reisa A. Sperling, Dan J. Stein, Aleks Stolicyn, John Suckling, Gemma Sullivan, Yasuyuki Taki, Benjamin Thyreau, Roberto Toro, Nicolas Traut, Kamen A. Tsvetanov, Nicholas B. Turk-Browne, Jetro J. Tuulari, Christophe Tzourio, Etienne Vachon-Presseau, Mitchell Valdes-Sosa, Pedro Valdes-Sosa, Sofie L. Valk, Therese van Amelsvoort, Simon Vandekar, Lana Vasung, Petra E Vertes, Lindsay W. Victoria, Sylvia Villeneuve, Arno Villringer, Konrad Wagstyl, Yin-Shan S. Wang, Simon K. Warfield, Varun Warrier, Eric Westman, Margaret L. Westwater, Heather C Whalley, A. Veronica Witte, Ning Yang, B.T. Thomas Yeo, H. J. Yun, Andrew Zalesky, Heather J. Zar, Anna Zettergren, Juan Helen Zhou, Hisham Ziauddeen, Andre Zugman, Xi-Nian Zuo, AIBL, Alzheimer's Disease Neuroimaging Initiative, Alzheimer's Disease Repository Without Borders Investigators, ASRB, CALM Team, Cam-CAN, CCNP, 3R-BRAIN, COBRE, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, NSPN, OASIS-3, OpenPain Project, POND, The PREVENT-AD Research Group, UMN BCP Consortium, VETSA, Ed Bullmore, Aaron Alexander-Bloch

Posted 10 Jun 2021
bioRxiv DOI: 10.1101/2021.06.08.447489

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here, we built an interactive resource to benchmark brain morphology, www.brainchart.io, derived from any current or future sample of magnetic resonance imaging (MRI) data. With the goal of basing these reference charts on the largest and most inclusive dataset available, we aggregated 123,984 MRI scans from 101,457 participants aged from 115 days post-conception through 100 postnatal years, across more than 100 primary research studies. Cerebrum tissue volumes and other global or regional MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3; showed high stability of individual centile scores over longitudinal assessments; and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared to non-centiled MRI phenotypes, and provided a standardised measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In sum, brain charts are an essential first step towards robust quantification of individual deviations from normative trajectories in multiple, commonly-used neuroimaging phenotypes. Our collaborative study proves the principle that brain charts are achievable on a global scale over the entire lifespan, and applicable to analysis of diverse developmental and clinical effects on human brain structure. Furthermore, we provide open resources to support future advances towards adoption of brain charts as standards for quantitative benchmarking of typical or atypical brain MRI scans.

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