Rxivist logo

Joint analysis of area and thickness as a replacement for the analysis of cortical volume

By Anderson Winkler, Douglas N. Greve, Knut J. Bjuland, Thomas E. Nichols, Mert R Sabuncu, Asta Kristine HÃ¥berg, Jon Skranes, Lars M. Rimol

Posted 11 Sep 2016
bioRxiv DOI: 10.1101/074666

Cortical surface area is an increasingly used brain morphology metric that is ontogenetically and phylogenetically distinct from cortical thickness and offers a separate index of neurodevelopment and disease. However, the various existing methods for assessment of cortical surface area from magnetic resonance images have never been systematically compared. We show that the surface area method implemented in FreeSurfer corresponds closely to the exact, but computationally more demanding, mass-conservative (pycnophylactic) method, provided that images are smoothed. Thus, the data produced by this method can be interpreted as estimates of cortical surface area, as opposed to areal expansion. In addition, focusing on the joint analysis of thickness and area, we compare an improved, analytic method for measuring cortical volume to a permutation based non-parametric combination (NPC) method. We use the methods to analyse area, thickness and volume in young adults born preterm with very low birth weight, and show that NPC analysis is a more sensitive option for studying joint effects on area and thickness, giving equal weight to variation in both of these two morphological features.

Download data

  • Downloaded 1,169 times
  • Download rankings, all-time:
    • Site-wide: 16,662
    • In neuroscience: 2,061
  • Year to date:
    • Site-wide: 61,909
  • Since beginning of last month:
    • Site-wide: 99,750

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News