Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,170 bioRxiv papers from 306,408 authors.
Default Mode Network patterns and its interactions with memory performance in patients with Temporal Lobe Epilepsy and controls
Patients with mesial temporal lobe epilepsy (MTLE) have cognitive dysfunctions not fully explained by the temporal seizure focus. Abnormal functional connectivity in the resting-state default mode network (DMN) appear to be related to these cognitive impairments. Studies showed DMN abnormalities in MTLE, but most combined patients with hippocampal sclerosis (HS) with other underlying etiologies. We enrolled 122 MTLE patients divided into right-HS (n=42), left-HS (n=49), MRI-negative MTLE (n=31) and controls (n=69). All underwent resting-state seed-based connectivity fMRI, with a seed placed at the posterior cingulate cortex, an essential node for the DMN. In addition, patients and 41 controls were tested for verbal and visual memory, estimated intelligence coefficient and delayed recall. Both right-HS and MRI-negative group presented the poorest visual memory scores. Also right-HS and left-HS had a worse performance in verbal memory compared to controls and MRI-negative groups. Overall, the presence of HS in the left hemisphere had more impact on verbal memory, which was not found when the seizure focus is in the left hemisphere in the absence of HS. MTLE patients presented an intricate pattern of increased and decreased connectivity regardless the presence or side of HS. As expected, hippocampus was less connected than controls in all groups of patients. Although EEGs indicated that 64.5% of MRI-negative patients were lateralized to the left, this group showed activations similar to the right-HS. Patients with left and right-HS presented similar, increased and decreased connectivity in the ipsilateral hemisphere; however, left-HS had abnormal decreased connectivity in the contralateral hemisphere.
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