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A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality
By
Tanya L Daigle,
Linda Madisen,
Travis A Hage,
Matthew T Valley,
Ulf Knoblich,
Rylan S Larsen,
Marc M Takeno,
Lawrence Huang,
Hong Gu,
Rachael Larsen,
Maya Mills,
Alice Bosma-Moody,
La’Akea Siverts,
Miranda Walker,
Lucas T Graybuck,
Zizhen Yao,
Olivia Fong,
Emma Garren,
Garreck Lenz,
Mariya Chavarha,
Julie Pendergraft,
James Harrington,
Karla E Hirokawa,
Julie A Harris,
Medea McGraw,
Douglas R Ollerenshaw,
Kimberly Smith,
Christopher A Baker,
Jonathan T Ting,
Susan M Sunkin,
Jerome Lecoq,
Michael Z Lin,
Edward S Boyden,
Gabe J Murphy,
Nuno da Costa,
Jack Waters,
Lu Li,
Bosiljka Tasic,
Hongkui Zeng
Posted 25 Nov 2017
bioRxiv DOI: 10.1101/224881
(published DOI: 10.1016/j.cell.2018.06.035)
Modern genetic approaches are powerful in providing access to diverse types of neurons within the mammalian brain and greatly facilitating the study of their function. We here report a large set of driver and reporter transgenic mouse lines, including 23 new driver lines targeting a variety of cortical and subcortical cell populations and 26 new reporter lines expressing an array of molecular tools. In particular, we describe the TIGRE2.0 transgenic platform and introduce Cre-dependent reporter lines that enable optical physiology, optogenetics, and sparse labeling of genetically-defined cell populations. TIGRE2.0 reporters broke the barrier in transgene expression level of single-copy targeted-insertion transgenesis in a wide range of neuronal types, along with additional advantage of a simplified breeding strategy compared to our first-generation TIGRE lines. These novel transgenic lines greatly expand the repertoire of high-precision genetic tools available to effectively identify, monitor, and manipulate distinct cell types in the mouse brain.
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