Analysis of Spounaviruses as a Case Study for the Overdue Reclassification of Tailed Bacteriophages
Bas E. Dutilh,
Margo BP Schuller,
Robert A Edwards,
Jens H. Kuhn,
Hanna M Oksanen,
Matthew B Sullivan,
J. Rodney Brister,
Andrew M Kropinski,
Evelien M. Adriaenssens
Posted 16 Nov 2017
bioRxiv DOI: 10.1101/220434 (published DOI: 10.1093/sysbio/syz036)
Posted 16 Nov 2017
It is almost a cliche that tailed bacteriophages of the order Caudovirales are the most abundant and diverse viruses in the world. Yet, their taxonomy still consists of a single order with just three families: Myoviridae, Siphoviridae, and Podoviridae. Thousands of newly discovered phage genomes have recently challenged this morphology-based classification, revealing that tailed bacteriophages are genomically even more diverse than once thought. Here, we evaluate a range of methods for bacteriophage taxonomy by using a particularly challenging group as an example, the Bacillus phage SPO1-related viruses of the myovirid subfamily Spounavirinae. Exhaustive phylogenetic and phylogenomic analyses indicate that the spounavirins are consistent with the taxonomic rank of family and should be divided into at least five subfamilies. This work is a case study for virus genomic taxonomy and the first step in an impending massive reorganization of the tailed bacteriophage taxonomy.
- Downloaded 1,289 times
- Download rankings, all-time:
- Site-wide: 11,610 out of 117,931
- In microbiology: 630 out of 9,328
- Year to date:
- Site-wide: 33,412 out of 117,931
- Since beginning of last month:
- Site-wide: 46,785 out of 117,931
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!