Rxivist logo

A population-based atlas of the human pyramidal tract in 410 healthy participants

By Quentin Chenot, Nathalie Tzourio-Mazoyer, Francois Rheault, Maxime Descoteaux, Fabrice Crivello, Laure Zago, Emmanuel Mellet, Gaƫl Jobard, Marc Joliot, Bernard Mazoyer, Laurent Petit

Posted 22 Jan 2018
bioRxiv DOI: 10.1101/251108 (published DOI: 10.1007/s00429-018-1798-7)

With the advances in diffusion MRI and tractography, numerous atlases of the human pyramidal tract (PyT) have been proposed but the inherent limitation of tractography to resolve crisscrossed bundles within the centrum semiovale have so far prevented the complete description of the most lateral PyT projections. Here, we combined a precise manual positioning of individual subcortical regions of interest along the descending pathway of the PyT with a new bundle-specific tractography algorithm. This later is based on anatomical priors to improve streamlines tracking in crossing areas. We then extracted both left and right PyT in a large cohort of 410 healthy participants and built a probabilistic atlas of the whole-fanning PyT with a complete description of its most cortico-lateral projections. Clinical applications are envisaged, the whole-fanning probabilistic PyT atlas being likely a better marker of corticospinal integrity metrics than those currently used within the frame of prediction of post-stroke motor recovery. The present probabilistic PyT, freely available, provides an interesting tool for clinical applications in order to locate specific PyT damage and its impact to the short and long-term motor recovery after stroke.

Download data

  • Downloaded 882 times
  • Download rankings, all-time:
    • Site-wide: 15,708 out of 100,591
    • In neuroscience: 2,535 out of 17,924
  • Year to date:
    • Site-wide: 37,128 out of 100,591
  • Since beginning of last month:
    • Site-wide: None out of 100,591

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


  • 20 Oct 2020: Support for sorting preprints using Twitter activity has been removed, at least temporarily, until a new source of social media activity data becomes available.
  • 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
  • 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
  • 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
  • 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
  • 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
  • 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
  • 22 Jan 2019: Nature just published an article about Rxivist and our data.
  • 13 Jan 2019: The Rxivist preprint is live!