Human Fronto-Striatal Connectivity is Organized into Discrete Functional Subnetworks
Evan M Gordon,
Timothy O. Laumann,
Dillan J. Newbold,
Jaqueline M Hampton,
Nicole A. Seider,
David F. Montez,
Ashley M. Nielsen,
Andrew N. Van,
Joshua S. Siegel,
Benjamin P. Kay,
Abraham Z. Snyder,
Deanna J. Greene,
Bradley L. Schlaggar,
Steven M Nelson,
Posted 12 Apr 2021
bioRxiv DOI: 10.1101/2021.04.12.439415
Posted 12 Apr 2021
The striatum is interconnected with the cerebral cortex via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate cortico-striatal connections can be precisely mapped using invasive tract-tracing. However, noninvasive human research has not mapped these connections with anatomical precision, limited by the practice of averaging neuroimaging data across individuals. Here we utilized highly-sampled resting-state functional connectivity MRI for individually-specific precision functional mapping of cortico-striatal connections. We identified ten discrete, individual-specific subnetworks linking cortex-predominately frontal cortex-to striatum. These subnetworks included previously unknown striatal connections to the human language network. The discrete subnetworks formed a stepped rostral-caudal gradient progressing from nucleus accumbens to posterior putamen; this organization was strongest for projections from medial frontal cortex. The stepped gradient organization fit patterns of fronto striatal connections better than a smooth, continuous gradient. Thus, precision subnetworks identify detailed, individual-specific stepped gradients of cortico-striatal connectivity that include human specific language networks.
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