Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,077 bioRxiv papers from 306,093 authors.
Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence
Nhat Trung Doan,
Linn Bonaventure Norbom,
Dennis van der Meer,
Ole A. Andreassen,
Lars T. Westlye
Posted 23 Mar 2018
bioRxiv DOI: 10.1101/288134
Posted 23 Mar 2018
Background: Accumulating evidence supports cerebellar involvement in mental disorders such as schizophrenia, bipolar disorder, depression, anxiety disorders and attention-deficit hyperactivity disorder. However, little is known about the cerebellum in developmental stages of these disorders. In particular, whether cerebellar morphology is associated with early expression of specific symptom domains remains unclear. Methods: We used machine learning to test whether cerebellar morphometric features could robustly predict general cognitive function and psychiatric symptoms in a large and well-characterized developmental community sample centered on adolescence (The Philadelphia Neurodevelopmental Cohort, N=1401, age-range: 8 - 23). Results: Cerebellar morphology was associated with both general cognitive function and general psychopathology (mean correlations between predicted and observed values: r = .20 and r = .13; p-values < .0009). Analyses of specific symptom domains revealed significant associations with rates of norm-violating behavior (r = .17; p < .0009), as well as psychosis (r = .12; p < .0009) and anxiety (r = .09; p =.0117) symptoms. In contrast, we observed no associations with attention deficits, depressive, manic or obsessive-compulsive symptoms. Crucially, across 52 brain-wide anatomical features, cerebellar features emerged as the most important for prediction of general psychopathology, psychotic symptoms and norm-violating behavior. Moreover, the association between cerebellar volume and psychotic symptoms, and to a lesser extent norm violating behavior, remained significant when adjusting for several potentially confounding factors. Conclusions: The robust associations with psychiatric symptoms in the age range when these typically emerge highlight the cerebellum as a key brain structure in the development of severe mental disorders.
- Downloaded 880 times
- Download rankings, all-time:
- Site-wide: 10,008 out of 70,077
- In neuroscience: 1,590 out of 12,597
- Year to date:
- Site-wide: 2,580 out of 70,077
- Since beginning of last month:
- Site-wide: 6,541 out of 70,077
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!