Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England
Daniel J Grint,
Helen I McDonald,
Stephen JW Evans,
Alex J Walker,
Christopher T Rentsch,
Helen J Curtis,
Caroline E Morton,
Sebastian CJ Bacon,
Angel YS Wong,
Ian J Douglas,
Nicolas J DeVito,
Rosalind M Eggo
Posted 08 Mar 2021
medRxiv DOI: 10.1101/2021.03.04.21252528
Posted 08 Mar 2021
The B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (HR: 1.67 (95% CI: 1.34 - 2.09; P<.0001). Absolute risk of death by 28-days increased with age and comorbidities. VOC has potential to spread faster with higher mortality than the pandemic to date.
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