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Anatomical predictors of successful prism adaptation in chronic visual neglect

By Marine Lunven, Gilles Rode, Clémence Bourlon, Christophe Duret, Raffaella Migliaccio, Emmanuel Chevrillon, Michel Thiebaut de Schotten, Paolo Bartolomeo

Posted 01 Jun 2017
bioRxiv DOI: 10.1101/144956 (published DOI: 10.1016/j.cortex.2018.12.004)

Background and Purpose. To assess the hypothesis that prism adaptation improves left neglect after right brain damage by facilitating compensation through the contribution of the left, undamaged hemisphere. Methods. We assessed the relationship between prism adaptation effects, cortical thickness and white matter integrity in a group of 14 patients with unilateral right-hemisphere strokes and chronic visual neglect. Results. Patients who benefitted from prism adaptation had thicker cortex in temporo-parietal, prefrontal and cingulate areas of the left, undamaged hemisphere. Additionally, these patients had a higher microstructural integrity in the body and genu of the corpus callosum. Results from normal controls show that these callosal regions connect temporo-parietal, sensorimotor and prefrontal areas. Finally, shorter time intervals from the stroke tended to improve the patients' response to prism adaptation. Conclusions. Prism adaptation appears to improve left visual neglect by promoting the contribution of the left hemisphere to neglect compensation. These results support current hypotheses on the role of the healthy hemisphere in the compensation for stroke-induced, chronic neuropsychological deficits, and suggest that prism adaptation can foster this role by exploiting sensorimotor/prefrontal circuits, especially when applied at early stages post-stroke.

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