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Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

By Hongyu Chen, Xin Qian, Xiaojiao Chen, Tongqing Yang, Mingfeng Feng, Jing Chen, Ruixiang Cheng, Hao Hong, Ying Zheng, Yuzhen Mei, Danyu Shen, Yi Xu, Min Zhu, Xin Shun Ding, Xiaorong Tao

Posted 24 Dec 2020
bioRxiv DOI: 10.1101/2020.12.24.424293

Plant intracellular nucleotide binding-leucine-rich repeat (NLR) receptors play critical roles in mediating host immunity to pathogen attack. Successful virus infection in plant involves several essential steps including viral replication, intercellular and long-distance movement. How plant NLRs induce resistances against virus infection remains largely unknown. We demonstrated here that tomato NLR Sw-5b locates to cytoplasm and nucleus, respectively, to play different roles in inducing host resistances against tospovirus infection. The cytoplasmic Sw-5b functions to induce a strong cell death response to inhibit TSWV replication. This host response is, however, insufficient to block viral intercellular and long-distance movement. The nucleus-localized Sw-5b triggers a host defense that weakly inhibit viral replication but strongly impede virus intercellular and systemic movement. Furthermore, the cytoplasmic and nuclear Sw-5b act synergistically to confer a strong immunity to TSWV infection. Our finding adds a new knowledge to our current understanding on the plant NLRs-triggered immunity against virus infection.

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