Common genetic variants identify therapeutic targets for COVID-19 and individuals at high risk of severe disease
By
Julie E. Horowitz,
Jack A. Kosmicki,
Amy Damask,
Deepika Sharma,
Genevieve H. L. Roberts,
Anne A. E. Justice,
Nilanjana Banerjee,
Marie V. Coignet,
Ashish Yadav,
Joseph B Leader,
Anthony Marcketta,
Danny S. Park,
Rouel Lanche,
Evan Maxwell,
Spencer C. Knight,
Xiaodong Bai,
Harenda Guturu,
Dylan Sun,
Asher Baltzell,
Fabricio S. P. Kury,
Joshua D Backman,
Ahna R. Girshick,
Colm O'Dushlaine,
Shannon R. McCurdy,
Raghavendran Partha,
Adam J Mansfield,
David A Turissini,
Alexander H Li,
Miao Zhang,
Joelle Mbatchou,
Kyoko Watanabe,
Lauren Gurski,
Shane E McCarthy,
Anurag Verma,
Giorgio Sirugo,
Regeneron Genetics Center,
Marylyn DeRiggi Ritchie,
Marcus Jones,
Suganthi Balasubramanian,
William J Salerno,
Alan R. Shuldiner,
Daniel J. Rader,
Tooraj Mirshahi,
Adam E Locke,
Jonathan Marchini,
John D Overton,
David J Carey,
Lukas Habegger,
Michael N Cantor,
Kristin A. Rand,
Eurie L. Hong,
Jeffrey G. Reid,
Catherine A Ball,
Aris Baras,
Goncalo R. Abecasis,
Manuel A. Ferreira
Posted 16 Dec 2020
medRxiv DOI: 10.1101/2020.12.14.20248176
The need to identify and effectively treat COVID-19 cases at highest risk for severe disease is critical. We identified seven common genetic variants (three novel) that modulate COVID-19 susceptibility and severity, implicating IFNAR2, CCHCR1, TCF19, SLC6A20 and the hyaluronan pathway as potential therapeutic targets. A high genetic burden was strongly associated with increased risk of hospitalization and severe disease among COVID-19 cases, especially among individuals with few known risk factors.
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