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Statistical shape analysis of large datasets based on diffeomorphic iterative centroids

By Claire Cury, Joan A. Glaun├Ęs, Roberto Toro, Marie Chupin, Gunter Shumann, Vincent Frouin, Jean-Baptiste Poline, Olivier Colliot, and the Consortium Imagen

Posted 06 Jul 2018
bioRxiv DOI: 10.1101/363861 (published DOI: 10.3389/fnins.2018.00803)

In this paper, we propose an approach for template-based shape analysis of large datasets, using diffeomorphic centroids as atlas shapes. Diffeomorphic centroid methods fit in the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework and use kernel metrics on currents to quantify surface dissimilarities. The statistical analysis is based on a Kernel Principal Component Analysis (Kernel PCA) performed on the set of momentum vectors which parametrize the deformations. We tested the approach on different datasets of hippocampal shapes extracted from brain magnetic resonance imaging (MRI), compared three different centroid methods and a variational template estimation. The largest dataset is composed of 1000 surfaces, and we are able to analyse this dataset in 26 hours using a diffeomorphic centroid. Our experiments demonstrate that computing diffeomorphic centroids in place of standard variational templates leads to similar shape analysis results and saves around 70% of computation time. Furthermore, the approach is able to adequately capture the variability of hippocampal shapes with a reasonable number of dimensions, and to predict anatomical features of the hippocampus in healthy subjects.

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