Schizophrenia is a complex, polygenic disorder associated with subtle, distributed abnormalities in brain morphology. Here, we report large genetic overlap between schizophrenia and brain morphology, which enabled derivation of polygenic risk scores more predictive of schizophrenia diagnosis than the current state-of-the-art. Our results illustrate the potential of exploiting genetic overlap in imaging genetics studies, and how pleiotropy-enriched risk scores may improve prediction of polygenic brain disorders.

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