SARS-CoV-2 Seroprevalence Among Parturient Women
Dustin D. Flannery,
Miren B. Dhudasia,
Madeline R. Pfeifer,
Emily C. Woodford,
Jeffrey S. Gerber,
Claudia P Arevalo,
Marcus J Bolton,
Madison E. Weirick,
Eileen C. Goodwin,
Elizabeth M Anderson,
Allison R. Greenplate,
Amy E. Baxter,
Laura A. Vella,
Jeffrey S Morris,
Daniel J Rader,
Michal A Elovitz,
E John Wherry,
Karen M. Puopolo,
Scott E Hensley
Posted 10 Jul 2020
medRxiv DOI: 10.1101/2020.07.08.20149179
Posted 10 Jul 2020
Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important to determine exposure and immunity to SARS-CoV-2 within both individuals and populations. We completed SARS-CoV-2 serological testing of 1,293 parturient women at two centers in Philadelphia from April 4 to June 3, 2020. We tested 834 pre-pandemic samples collected in 2019 and 15 samples from COVID-19 recovered donors to validate our assay, which has a ~1% false positive rate. We found 80/1,293 (6.2%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies. We found race/ethnicity differences in seroprevalence rates, with higher rates in Black/non-Hispanic and Hispanic/Latino women. Of the 72 seropositive women who also received nasopharyngeal polymerase chain reaction testing during pregnancy, 46 (64%) were positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate seroprevalence within the community.
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