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A two-state ribosome and protein model can robustly capture the chemical reaction dynamics of gene expression

By Ayush Pandey, Richard M. Murray

Posted 26 Nov 2020
bioRxiv DOI: 10.1101/2020.11.25.399287

We derive phenomenological models of gene expression from a mechanistic description of chemical reactions using an automated model reduction method. Using this method, we get analytical descriptions and computational performance guarantees to compare the reduced dynamics with the full models. We develop a new two-state model with the dynamics of the available free ribosomes in the system and the protein concentration. We show that this new two-state model captures the detailed mass-action kinetics of the chemical reaction network under various biologically plausible conditions on model parameters. On comparing the performance of this model with the commonly used mRNA transcript-protein dynamical model for gene expression, we analytically show that the free ribosome and protein model has superior error and robustness performance.

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