Rxivist logo

Innate immune signaling in the olfactory epithelium reduces odorant receptor levels: modeling transient smell loss in COVID-19 patients

By Steve Rodriguez, Luxiang Cao, Gregory T. Rickenbacher, Eric G. Benz, Colin Magdamo, Liliana A Ramirez Gomez, Eric Holbrook, Alefiya Dhilla Albers, Rose Gallagher, M Brandon Westover, Kyle E. Evans, Daniel Tatar, Shibani Mukerji, Ross Zafonte, Edward W. Boyer, Ron Yu, Mark W. Albers

Posted 16 Jun 2020
medRxiv DOI: 10.1101/2020.06.14.20131128

Post-infectious anosmias typically follow death of olfactory sensory neurons (OSNs) with a months-long recovery phase associated with parosmias. While profound anosmia is the leading symptom associated with COVID-19 infection, many patients regain olfactory function within days to weeks without distortions. Here, we demonstrate that sterile induction of anti-viral type I interferon signaling in the mouse olfactory epithelium is associated with diminished odor discrimination and reduced odor-evoked local field potentials. RNA levels of all class I, class II, and TAAR odorant receptors are markedly reduced in OSNs in a non-cell autonomous manner. We find that people infected with COVID-19 rate odors with lower intensities and have odor discrimination deficits relative to people that tested negative for COVID-19. Taken together, we propose that inflammatory-mediated loss of odorant receptor expression with preserved circuit integrity accounts for the profound anosmia and rapid recovery of olfactory function without parosmias caused by COVID-19.

Download data

  • Downloaded 1,476 times
  • Download rankings, all-time:
    • Site-wide: 16,411
    • In neurology: 41
  • Year to date:
    • Site-wide: 31,870
  • Since beginning of last month:
    • Site-wide: 15,699

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide