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Prediction of 7-year's Conversion from Subjective Cognitive Decline to Mild Cognitive Impairment

By Ling Yue, Dan Hu, Han Zhang, Junhao Wen, Ye Wu, Wei Li, Lin Sun, Xia Li, Jinghua Wang, Guanjun Li, Tao Wang, Dinggang Shen, Shifu Xiao

Posted 08 May 2020
medRxiv DOI: 10.1101/2020.05.04.20091256

Subjective cognitive decline (SCD) is a high-risk yet less understood status years before Alzheimer's disease (AD). This work included 76 SCD individuals with two (baseline and seven years later) neuropsychological evaluations and a baseline T1-MRI. A machine learning-based model was trained based on 198 baseline neuroimage features and a battery of 25 clinical measurements to discriminate 24 progressive SCDs from 52 stable SCDs. The SCD progression was satisfactorily predicted with combined features. A history of stroke, a low education level, a low baseline MoCA score, a shrunk left amygdala, and enlarged white matter at the banks of the right superior temporal sulcus favor the progression. This is to date the largest retrospective study of SCD-to-MCI conversion with the longest follow-up, suggesting predictable far-future cognitive decline for the risky populations with baseline measures only. These findings provide valuable knowledge to the future neuropathological studies of AD in its prodromal phase.

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