Cell specific eQTL analysis without sorting cells
Marjolein J. Peters,
Benjamin Peter Fairfax,
Anand Kumar Andiappan,
André G. Uitterlinden,
Andrew R. Wood,
Andrew B. Singleton,
Dena G. Hernandez,
Julian C. Knight,
De Yun Wang,
Leonard H. van den Berg,
Jan H. Veldink,
Timouthy M. Frayling,
Joyce B. J. van Meurs,
Ritsert C. Jansen,
Posted 12 Feb 2014
bioRxiv DOI: 10.1101/002600 (published DOI: 10.1371/journal.pgen.1005223)
Posted 12 Feb 2014
Expression quantitative trait locus (eQTL) mapping on tissue, organ or whole organism data can detect associations that are generic across cell types. We describe a new method to focus upon specific cell types without first needing to sort cells. We applied the method to whole blood data from 5,683 samples and demonstrate that SNPs associated with Crohns disease preferentially affect gene expression within neutrophils.
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