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Expression quantitative trait locus (eQTL) mapping on tissue, organ or whole organism data can detect associations that are generic across cell types. We describe a new method to focus upon specific cell types without first needing to sort cells. We applied the method to whole blood data from 5,683 samples and demonstrate that SNPs associated with Crohn’s disease preferentially affect gene expression within neutrophils.

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  • Download rankings, all-time:
    • Site-wide: 2,968 out of 70,836
    • In genetics: 257 out of 3,925
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