Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,351 bioRxiv papers from 289,484 authors.
Regulatory variants explain much more heritability than coding variants across 11 common diseases
S. Hong Lee,
Benjamin M Neale,
Bjarni J Vilhjálmsson,
Schizophrenia Working Group of the Psychiatric Genomics Consortium,
Anna K Kähler,
Christina M Hultman,
Shaun M. Purcell,
Steven A McCarroll,
Patrick F Sullivan,
Naomi R. Wray,
Alkes L. Price
Posted 21 Apr 2014
bioRxiv DOI: 10.1101/004309
Posted 21 Apr 2014
Common variants implicated by genome-wide association studies (GWAS) of complex diseases are known to be enriched for coding and regulatory variants. We applied methods to partition the heritability explained by genotyped SNPs (h2g) across functional categories (while accounting for shared variance due to linkage disequilibrium) to genotype and imputed data for 11 common diseases. DNaseI Hypersensitivity Sites (DHS) from 218 cell-types, spanning 16% of the genome, explained an average of 79% of h2g (5.1× enrichment; P < 10−20); further enrichment was observed at enhancer and cell-type specific DHS elements. The enrichments were much smaller in analyses that did not use imputed data or were restricted to GWAS- associated SNPs. In contrast, coding variants, spanning 1% of the genome, explained only 8% of h2g (13.8× enrichment; P = 5 × 10−4). We replicated these findings but found no significant contribution from rare coding variants in an independent schizophrenia cohort genotyped on GWAS and exome chips.
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