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Post-Exertional Malaise in People with Chronic Cancer-Related Fatigue

By Rosie Twomey, Samuel T. Yeung, James G Wrightson, Guillaume Y Millet, S. Nicole Culos-Reed

Posted 15 Dec 2019
medRxiv DOI: 10.1101/2019.12.12.19014829

ContextCancer-related fatigue (CRF) is a distressing and persistent sense of tiredness or exhaustion that interferes with usual functioning. Chronic CRF continues for months after curative cancer treatment is complete. Post-exertional malaise (PEM) is a worsening of symptoms after physical or mental activity, with limited investigations in people with chronic CRF. ObjectivesThe purpose of this study was to identify and describe self-reported incidences of PEM in people with chronic CRF. MethodsParticipants (n=18) were eligible if they scored [≤]34 on the Functional Assessment of Chronic Illness Therapy-Fatigue scale and had a cancer-related onset of fatigue. Participants completed a brief questionnaire to assess PEM over a 6-month time-frame (the DePaul Symptom Questionnaire - Post-Exertional Malaise; DSQ-PEM). In addition, a maximal exercise test was used to investigate self-reported symptom exacerbation (via an open-ended questionnaire) after strenuous physical exertion. ResultsOn the DSQ-PEM, three participants met previously defined scoring criteria, which included experiencing moderate to very severe symptoms at least half of the time, worsening of fatigue after minimal effort, plus a recovery duration of >24 h. Content analysis of responses to open-ended questionnaires identified five people who experienced a delayed recovery and symptoms of PEM after maximal exercise. ConclusionA subset of people with chronic CRF (up to 33% in this sample) may experience PEM. Exercise specialists and health care professionals working with people with chronic CRF must be aware that PEM may be an issue. Symptom exacerbation after exercise should be monitored, and exercise should be tailored and adapted to limit the potential for harm. Key messageThis study provides preliminary evidence that a subset of people with chronic cancer-related fatigue experience post-exertional malaise.

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