Rxivist logo

Fulfilling the promise of Mendelian randomization

By Joseph K. Pickrell

Posted 16 Apr 2015
bioRxiv DOI: 10.1101/018150

Many important questions in medicine involve questions about causality, For example, do low levels of high-density lipoproteins (HDL) cause heart disease? Does high body mass index (BMI) cause type 2 diabetes? Or are these traits simply correlated in the population for other reasons? A popular approach to answering these problems using human genetics is called "Mendelian randomization". We discuss the prospects and limitations of this approach, and some ways forward.

Download data

  • Downloaded 4,488 times
  • Download rankings, all-time:
    • Site-wide: 822 out of 83,751
    • In genetics: 64 out of 4,399
  • Year to date:
    • Site-wide: 44,511 out of 83,751
  • Since beginning of last month:
    • Site-wide: 39,673 out of 83,751

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)