Genetic Basis of Transcriptome Diversity in Drosophila melanogaster

Understanding how DNA sequence variation is translated into variation for complex phenotypes has remained elusive, but is essential for predicting adaptive evolution, selecting agriculturally important animals and crops, and personalized medicine. Here, we quantified genome-wide variation in gene expression in the sequenced inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP). We found that a substantial fraction of the Drosophila transcriptome is genetically variable and organized into modules of genetically correlated transcripts, which provide functional context for newly identified transcribed regions. We identified regulatory variants for the mean and variance of gene expression, the latter of which could often be explained by an epistatic model. Expression quantitative trait loci for the mean, but not the variance, of gene expression were concentrated near genes. This comprehensive characterization of population scale diversity of transcriptomes and its genetic basis in the DGRP is critically important for a systems understanding of quantitative trait variation.

Download data

• Downloaded 737 times
• Download rankings, all-time:
  • Site-wide: 29,987
  • In genetics: 1,486
• Year to date:
  • Site-wide: 92,632
• Since beginning of last month:
  • Site-wide: 92,632

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide