A reference panel of 64,976 haplotypes for genotype imputation
Andrew R. Wood,
Hyun Min Kang,
Laura J Scott,
Cornelia Van Duijn,
Christopher E Gillies,
Dorret I. Boomsma,
Francis S Collins,
George Davey Smith,
Ross M Fraser,
Sean E. Levy,
Oddgeir L Holmen,
Karen L. Mohlke,
P. Eline Slagboom,
Leonard Van den Berg,
Wouter Van Rheenen,
Matthew G. Sampson,
James F Wilson,
Paul de Bakker,
Morris A. Swertz,
Mark I McCarthy,
Posted 23 Dec 2015
bioRxiv DOI: 10.1101/035170 (published DOI: 10.1038/ng.3643)
Posted 23 Dec 2015
We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1%, a large increase in the number of SNPs tested in association studies and can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.
- Downloaded 4,544 times
- Download rankings, all-time:
- Site-wide: 1,081 out of 106,159
- In genetics: 78 out of 5,105
- Year to date:
- Site-wide: 75,802 out of 106,159
- Since beginning of last month:
- Site-wide: 66,786 out of 106,159
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!