Rxivist logo

The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro

By Evelina Statkute, Anzelika Rubina, Valerie O'Donnell, David Thomas, Richard J Stanton

Posted 13 Nov 2020
bioRxiv DOI: 10.1101/2020.11.13.381079

The ability of widely-available mouthwashes to inactivate SARS-CoV-2 in vitro was tested using a protocol capable of detecting a 5-log10 reduction in infectivity, under conditions mimicking the naso/oropharynx. During a 30 second exposure, two rinses containing cetylpyridinium chloride and a third with ethanol/ethyl lauroyl arginate eliminated live virus to EN14476 standards (>4-log10 reduction), while others with ethanol/essential oils and povidone-iodine (PVP-I) eliminated virus by 2-3-log10. Chlorhexidine or ethanol alone had little or no ability to inactivate virus in this assay. Studies are warranted to determine whether these formulations can inactivate virus in the human oropharynx in vivo, and whether this might impact transmission.

Download data

  • Downloaded 44,614 times
  • Download rankings, all-time:
    • Site-wide: 130
    • In microbiology: 12
  • Year to date:
    • Site-wide: 222
  • Since beginning of last month:
    • Site-wide: 341

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

News