Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 70,186 bioRxiv papers from 306,470 authors.

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

By Jacqueline M Lane, Jingjing Liang, Irma Vlasac, Simon G Anderson, David A Bechtold, Jack Bowden, Richard Emsley, Shubhroz Gill, Max A Little, AnneMarie I Luik, Andrew Loudon, Frank AJL Scheer, Shaun Purcell, Simon D Kyle, Deborah A. Lawlor, Xiaofeng Zhu, Susan Redline, David W. Ray, Martin K. Rutter, Richa Saxena

Posted 24 Oct 2016
bioRxiv DOI: 10.1101/082792 (published DOI: 10.1038/ng.3749)

Chronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality1,2, affect 25-30% of adults worldwide3. While environmental factors contribute importantly to self-reported habitual sleep duration and disruption, these traits are heritable4-9, and gene identification should improve our understanding of sleep function, mechanisms linking sleep to disease, and development of novel therapies. We report single and multi-trait genome-wide association analyses (GWAS) of self-reported sleep duration, insomnia symptoms including difficulty initiating and/or maintaining sleep, and excessive daytime sleepiness in the UK Biobank (n=112,586), with discovery of loci for insomnia symptoms (near MEIS1, TMEM132E, CYCL1, TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR/OPHN1) and a composite sleep trait (near INADL and HCRTR2), as well as replication of a locus for sleep duration (at PAX-8). Genetic correlation was observed between longer sleep duration and schizophrenia (rG=0.29, p=1.90x10-13) and between increased excessive daytime sleepiness and increased adiposity traits (BMI rG=0.20, p=3.12x10-09; waist circumference rG=0.20, p=2.12x10-07). Note: Martin K Rutter and Richa Saxena contributed equally and are joint senior authors on this manuscript.

Download data

  • Downloaded 1,215 times
  • Download rankings, all-time:
    • Site-wide: 5,923 out of 70,186
    • In genetics: 471 out of 3,896
  • Year to date:
    • Site-wide: 12,407 out of 70,186
  • Since beginning of last month:
    • Site-wide: 22,724 out of 70,186

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News