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deMeta: Removing sub-studies from meta-analysis of genome wide association studies (GWAS)

By Jiangming Sun, Yunpeng Wang

Posted 26 Oct 2020
bioRxiv DOI: 10.1101/2020.10.25.354191

Summary: Post-GWAS studies using the results from large consortium meta-analysis often need to correctly take care of the overlapping sample issue. The gold standard approach for resolving this issue is to reperform the GWAS or meta-analysis excluding the overlapped participants. However, such approach is time-consuming and, sometimes, restricted by the available data. deMeta provides a user friendly and computationally efficient command-line implementation for removing the effect of a contributing sub-study to a consortium from the meta-analysis results. Only the summary statistics of the meta-analysis the sub-study to be removed are required. In addition, deMeta can generate contrasting Manhattan and quantile-quantile plots for users to visualize the impact of the sub-study on the meta-analysis results. Availability and Implementation: The python source code, examples and documentations of deMeta are publicly available at https://github.com/Computational-NeuroGenetics/deMeta-beta . ### Competing Interest Statement The authors have declared no competing interest.

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