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SM-Omics: An automated platform for high-throughput spatial multi-omics

By Sanja Vickovic, Britta Loetstedt, Johanna Klughammer, Asa Segerstolpe, Orit Rozenblatt-Rosen, Aviv Regev

Posted 15 Oct 2020
bioRxiv DOI: 10.1101/2020.10.14.338418

The spatial organization of cells and molecules plays a key role in tissue function in homeostasis and disease. Spatial Transcriptomics (ST) has recently emerged as a key technique to capture and positionally barcode RNAs directly in tissues. Here, we advance the application of ST at scale, by presenting Spatial Multiomics (SM-Omics) as a fully automated high-throughput platform for combined and spatially resolved transcriptomics and antibody-based proteomics. ### Competing Interest Statement A.R. is a founder and equity holder of Celsius Therapeutics, an equity holder in Immunitas Therapeutics and until August 31, 2020 was an SAB member of Syros Pharmaceuticals, Neogene Therapeutics, Asimov and ThermoFisher Scientific. From August 1, 2020, A.R. is an employee of Genentech. S.V. and A.R. are co-inventors on PCT/US2020/015481 relating to this work.

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