Psychiatric Genomics: An Update and an Agenda
Patrick F. Sullivan,
Cynthia M Bulik,
Ole A. Andreassen,
Anders D. Børglum,
Howard J Edenberg,
Stephen V. Faraone,
Carol A Mathews,
Caroline M. Nievergelt,
Jordan W. Smoller,
Michael C O’Donovan,
for the Psychiatric Genomics Consortium
Posted 10 Mar 2017
bioRxiv DOI: 10.1101/115600 (published DOI: 10.1176/appi.ajp.2017.17030283)
Posted 10 Mar 2017
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders, particularly given its dedication to rapid progress and open science. The PGC has recently commenced a program of research designed to deliver “actionable” findings - genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. The emerging findings suggest that we are entering into a phase of accelerated translation of genetic discoveries to impact psychiatric practice within a precision medicine framework.
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