Author: Lei Zhang

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Preprints

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

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Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin

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  • Site-wide: 7
  • In microbiology: 1
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  • Site-wide: 585

Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China

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  • Site-wide: 346
  • In microbiology: 40
• Year to date:
  • Site-wide: 3,244
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  • Site-wide: 2,904

Variability in the analysis of a single neuroimaging dataset by many teams

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  • Site-wide: 1,195
  • In neuroscience: 58
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  • Site-wide: 5,910
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  • Site-wide: 6,078

Pericyte-specific vascular expression of SARS-CoV-2 receptor ACE2 – implications for microvascular inflammation and hypercoagulopathy in COVID-19

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  • Site-wide: 1,483
  • In pathology: 14
• Year to date:
  • Site-wide: 1,885
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  • Site-wide: 1,695

Sequence and annotation of 42 cannabis genomes reveals extensive copy number variation in cannabinoid synthesis and pathogen resistance genes

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  • Site-wide: 2,164
  • In genomics: 259
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  • Site-wide: 1,808
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  • Site-wide: 2,339

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

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  • Site-wide: 3,565
  • In biophysics: 57
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  • Site-wide: 4,798
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  • Site-wide: 7,559

COVID-19 Myocarditis and Severity Factors： An Adult Cohort Study

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  • Site-wide: 3,835
  • In infectious diseases: 615
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  • Site-wide: 8,100
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  • Site-wide: 4,549

Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV

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  • Site-wide: 3,968
  • In infectious diseases: 623
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  • Site-wide: 62,651

Lockdown may partially halt the spread of 2019 novel coronavirus in Hubei province, China

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  • Site-wide: 4,701
  • In infectious diseases: 702
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  • Site-wide: 39,948

Revealing neuro-computational mechanisms of reinforcement learning and decision-making with the hBayesDM package

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  • Site-wide: 5,697
  • In neuroscience: 560
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Reversing Glial Scar Back To Neural Tissue Through NeuroD1-Mediated Astrocyte-To-Neuron Conversion

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  • Site-wide: 6,953
  • In neuroscience: 730
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What is required to prevent a second major outbreak of the novel coronavirus SARS-CoV-2 upon lifting the metropolitan-wide quarantine of Wuhan city, China

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  • Site-wide: 7,111
  • In infectious diseases: 885
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  • Site-wide: 103,639

TITER: predicting translation initiation sites by deep learning

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  • Site-wide: 8,050
  • In bioinformatics: 1,022
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  • Site-wide: 102,975

Genome-wide variations of SARS-CoV-2 infer evolution relationship and transmission route

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  • Site-wide: 8,078
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  • Site-wide: 22,426

AN INTERACTIVE COVID-19 MOBILITY IMPACT AND SOCIAL DISTANCING ANALYSIS PLATFORM

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  • Site-wide: 9,143
  • In infectious diseases: 1,018
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  • Site-wide: 11,007
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  • Site-wide: 6,322

Reduced Default Mode Network Functional Connectivity in Patients with Recurrent Major Depressive Disorder

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  • Site-wide: 9,491
  • In neuroscience: 1,053
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  • Site-wide: 63,352

High-depth resequencing reveals hybrid population and insecticide resistance characteristics of fall armyworm (Spodoptera frugiperda) invading China

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  • Site-wide: 11,423
  • In genomics: 1,298
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  • Site-wide: 58,661

A brain network supporting social influences in human decision-making

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  • Site-wide: 11,814
  • In neuroscience: 1,385
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  • Site-wide: 82,433

DeepHINT: Understanding HIV-1 integration via deep learning with attention

• Downloaded 978 times
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  • Site-wide: 18,688
  • In bioinformatics: 2,308
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  • Site-wide: 31,389
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  • Site-wide: 47,460

Generating Templates and Growth Charts for School-Aged Brain Development

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  • Site-wide: 25,695
  • In neuroscience: 3,463
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  • Site-wide: None
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SCCNV: a software tool for identifying copy number variation from single-cell whole-genome sequencing

• Downloaded 777 times
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  • Site-wide: 25,986
  • In bioinformatics: 3,103
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  • Site-wide: 116,770

AutoGenome: An AutoML Tool for Genomic Research

• Downloaded 733 times
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  • Site-wide: 28,191
  • In genomics: 2,632
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  • Site-wide: 47,314

Fast-Bonito: A Faster Basecaller for Nanopore Sequencing

• Downloaded 689 times
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  • Site-wide: 30,644
  • In bioinformatics: 3,542
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  • Site-wide: 4,210

Development and clinical application of a rapid and sensitive loop-mediated isothermalamplification test for SARS-CoV-2 infection

• Downloaded 685 times
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  • Site-wide: 30,940
  • In infectious diseases: 1,809
• Year to date:
  • Site-wide: 42,095
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  • Site-wide: 22,819

Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria

• Downloaded 674 times
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  • Site-wide: 31,641
  • In biochemistry: 789
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  • Site-wide: 52,755

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer's disease

• Downloaded 621 times
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  • Site-wide: 35,203
  • In systems biology: 829
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  • Site-wide: None
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  • Site-wide: 74,480

Reconstruction of cell spatial organization based on ligand-receptor mediated self-assembly

• Downloaded 608 times
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  • Site-wide: 36,151
  • In bioinformatics: 4,043
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  • Site-wide: None
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  • Site-wide: 56,438

An optimized 16S rRNA sequencing protocol for vaginal microbiome to avoid biased abundance estimation

• Downloaded 582 times
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  • Site-wide: 38,126
  • In microbiology: 2,286
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  • Site-wide: None
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  • Site-wide: None

Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan

• Downloaded 580 times
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  • Site-wide: 38,303
  • In genomics: 3,256
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  • Site-wide: None
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  • Site-wide: 108,312

HIV-1 Envelope and MPER antibody structures in lipid assemblies

• Downloaded 579 times
• Download rankings, all-time:
  • Site-wide: 38,356
  • In immunology: 1,002
• Year to date:
  • Site-wide: 21,669
• Since beginning of last month:
  • Site-wide: 49,975

Projected COVID-19 epidemic in the United States in the context of the effectiveness of a potential vaccine and implications for social distancing and face mask use

• Downloaded 577 times
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  • Site-wide: 38,593
  • In infectious diseases: 2,023
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  • Site-wide: None
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  • Site-wide: 13,677

Regeneration of dorsal spinal cord neurons after injury via in situ NeuroD1-mediated astrocyte-to-neuron conversion

• Downloaded 568 times
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  • Site-wide: 39,376
  • In neuroscience: 5,694
• Year to date:
  • Site-wide: 34,083
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  • Site-wide: 26,407

Single-cell whole-genome sequencing reveals mutational landscapes of DNA mismatch repair deficiency in mouse primary fibroblasts

• Downloaded 550 times
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  • Site-wide: 40,992
  • In genomics: 3,397
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  • Site-wide: None
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  • Site-wide: 84,907

A general model to explain repeated turnovers of sex determination in the Salicaceae

• Downloaded 526 times
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  • Site-wide: 43,320
  • In genomics: 3,563
• Year to date:
  • Site-wide: 17,868
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  • Site-wide: 51,754

Functional Analysis of FRIGIDA Using Naturally Occurring Variation in Arabidopsis thaliana

• Downloaded 505 times
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  • Site-wide: 45,381
  • In plant biology: 1,068
• Year to date:
  • Site-wide: 47,836
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  • Site-wide: 59,429

Dissecting the dilemma between in vitro and in vivo drug screening: treating HepG2 cells with Artesunate as a model

• Downloaded 468 times
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  • Site-wide: 49,453
  • In cell biology: 2,174
• Year to date:
  • Site-wide: 52,124
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  • Site-wide: 36,926

Amorphous nickel titanium alloy film: a new choice for cryo electron microscopy sample preparation

• Downloaded 468 times
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  • Site-wide: 49,534
  • In biophysics: 1,738
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  • Site-wide: None
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  • Site-wide: 38,055

Gene editing of the multi-copy H2A.B gene family by a single pair of TALENS

• Downloaded 453 times
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  • Site-wide: 51,288
  • In genomics: 4,012
• Year to date:
  • Site-wide: 61,021
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  • Site-wide: 79,754

The impact of containment measures and air temperature on mitigating the transmission of COVID-19: a novel data-based comprehensive modeling analysis

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  • Site-wide: 51,731
  • In public and global health: 584
• Year to date:
  • Site-wide: 24,842
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  • Site-wide: 20,322

The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

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  • Site-wide: 52,085
  • In genomics: 4,051
• Year to date:
  • Site-wide: 20,234
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  • Site-wide: 20,248

Rational design of hepatitis C virus E2 core nanoparticle vaccines

• Downloaded 435 times
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  • Site-wide: 53,644
  • In microbiology: 3,441
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  • Site-wide: None
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  • Site-wide: 109,410

Genome-wide association study of appendicular lean mass in UK Biobank cohort

• Downloaded 428 times
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  • Site-wide: 54,646
  • In genetics: 2,644
• Year to date:
  • Site-wide: 30,164
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  • Site-wide: 60,352

AutoGenome V2: New Multimodal Approach Developed for Multi-Omics Research

• Downloaded 418 times
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  • Site-wide: 55,924
  • In bioinformatics: 5,682
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  • Site-wide: None
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  • Site-wide: 97,199

Characterization of fluorescent proteins with intramolecular photostabilization

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  • Site-wide: 57,359
  • In biophysics: 2,084
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  • Site-wide: 13,675
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  • Site-wide: 19,243

Spontaneous retrotranspositions in normal tissues are rare and associated with cell-type-specific differentiation

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  • Site-wide: 58,382
  • In genomics: 4,378
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  • Site-wide: 100,838

Chemistry of cation hydration and conduction in a skeletal muscle ryanodine receptor

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  • Site-wide: 60,664
  • In biochemistry: 1,661
• Year to date:
  • Site-wide: 48,103
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  • Site-wide: 60,331

miRNAs play important roles in aroma weakening during the shelf life of 'Nanguo' pear after cold storage

• Downloaded 367 times
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  • Site-wide: 63,454
  • In molecular biology: 1,867
• Year to date:
  • Site-wide: 46,152
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  • Site-wide: 46,321

Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

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  • Site-wide: 63,589
  • In oncology: 73
• Year to date:
  • Site-wide: 17,605
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  • Site-wide: 15,488

High-quality de novo genome assembly of Kappaphycus alvarezii based on both PacBio and HiSeq sequencing

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  • Site-wide: 65,026
  • In genomics: 4,647
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  • Site-wide: 16,678
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  • Site-wide: 45,976

The mechanosensitive Piezo1 orchestrating angiogenesis is essential in bone fracture repair

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  • Site-wide: 67,718
  • In systems biology: 1,685
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  • Site-wide: 89,246

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

• Downloaded 312 times
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  • Site-wide: 72,893
  • In cancer biology: 2,165
• Year to date:
  • Site-wide: 11,741
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  • Site-wide: 24,114

Effects of New York's Executive Order on Face Mask Use on COVID-19 Infections and Mortality: A Modeling Study

• Downloaded 303 times
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  • Site-wide: 74,415
  • In infectious diseases: 2,762
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  • Site-wide: None
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  • Site-wide: 62,021

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 294 times
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  • Site-wide: 76,228
  • In genetics: 3,593
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  • Site-wide: 93,701

Early detection of retinal alteration by visible and near-infrared optical coherence tomography (vnOCT) in a dexamethasone-induced ocular hypertension mouse model

• Downloaded 267 times
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  • Site-wide: 81,507
  • In bioengineering: 1,553
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  • Site-wide: 55,649
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  • Site-wide: 56,315

Performance of bitumen coating sheet using biomass pyrolysis oil

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  • Site-wide: 81,473
  • In bioengineering: 1,555
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  • Site-wide: None
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  • Site-wide: 72,826

The stability and ABA import activity of NRT1.2 in Arabidopsis are regulated by CEPR2 via phosphorylation modification

• Downloaded 256 times
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  • Site-wide: 83,952
  • In molecular biology: 2,499
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  • Site-wide: 43,133

Mendelian randomization analysis revealed causal effects from gut microbiota to abdominal obesity

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  • Site-wide: 90,963
  • In genomics: 5,636
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  • Site-wide: 73,475

Dix-seq: An integrated pipeline for fast amplicon data analysis

• Downloaded 213 times
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  • Site-wide: 92,840
  • In bioinformatics: 8,109
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  • Site-wide: 28,897
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  • Site-wide: 28,519

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

• Downloaded 205 times
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  • Site-wide: 94,579
  • In systems biology: 2,263
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  • Site-wide: None
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  • Site-wide: 63,960

CNSA: a data repository for archiving omics data

• Downloaded 199 times
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  • Site-wide: 95,771
  • In genomics: 5,800
• Year to date:
  • Site-wide: 18,869
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  • Site-wide: 43,808

CTCF-binding element regulates ESC differentiation via orchestrating long-range chromatin interaction between enhancers and HoxA

• Downloaded 179 times
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  • Site-wide: 99,821
  • In developmental biology: 2,756
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  • Site-wide: 23,954
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  • Site-wide: 33,039

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosis by Deep Neural Networks

• Downloaded 174 times
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  • Site-wide: 100,851
  • In microbiology: 7,474
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  • Site-wide: None
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  • Site-wide: 46,563

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

• Downloaded 166 times
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  • Site-wide: 102,518
  • In neuroscience: 15,980
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  • Site-wide: None
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  • Site-wide: 18,099

VirusDIP: Virus Data Integration Platform

• Downloaded 163 times
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  • Site-wide: 103,089
  • In bioinformatics: 8,699
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  • Site-wide: None
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  • Site-wide: 105,699

Genomic assessment of within-host population variation in Neisseria gonorrhoeae: Implications for gonorrhoea transmission

• Downloaded 160 times
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  • Site-wide: 103,681
  • In infectious diseases: 3,347
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  • Site-wide: 24,455
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  • Site-wide: 22,093

Transcriptome analysis of Fenneropenaeus chinensis (Decapoda: Penaeidae) after low-salinity exposure identifies differentially expressed genes in pathways potentially related to osmoregulation

• Downloaded 77 times
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  • Site-wide: 117,819
  • In physiology: 1,452
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  • Site-wide: None
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  • Site-wide: 30,485

LACCASE is Necessary for Root Development in Salvia miltiorrhiza

• Downloaded 76 times
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  • Site-wide: 118,015
  • In plant biology: 3,321
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  • Site-wide: 15,958
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  • Site-wide: 28,098

Long-range gene regulation network of the MGMT enhancer in modulating glioma cell sensitivity to temozolomide

• Downloaded 74 times
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  • Site-wide: 118,311
  • In genetics: 5,139
• Year to date:
  • Site-wide: 38,235
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  • Site-wide: 29,817

Membrane Env liposomes for immunization with HIV spikes

• Downloaded 62 times
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  • Site-wide: 119,888
  • In immunology: 3,374
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 8,490