Author: Yang Li

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Preprints

In-House Forecasting of Crop Latitude Adaptation through a Daylength-sensing-based Environment Adaptation Simulator (DEAS)

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Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

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  • Site-wide: 308
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SnapATAC: A Comprehensive Analysis Package for Single Cell ATAC-seq

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  • Site-wide: 915
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Global profiling of SARS-CoV-2 specific IgG/ IgM responses of convalescents using a proteome microarray

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  • Site-wide: 1,387
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  • Site-wide: 16,319

Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China

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  • Site-wide: 2,576
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  • Site-wide: 22,205

Suppressive myeloid cells are a hallmark of severe COVID-19

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  • Site-wide: 2,749
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  • Site-wide: 4,650
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  • Site-wide: 3,866

A survey of spiking activity reveals a functional hierarchy of mouse corticothalamic visual areas

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  • Site-wide: 2,806
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The cross-sectional study of hospitalized coronavirus disease 2019 patients in Xiangyang, Hubei province

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  • Site-wide: 3,548
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  • Site-wide: 72,819

A descriptive study of the impact of diseases control and prevention on the epidemics dynamics and clinical features of SARS-CoV-2 outbreak in Shanghai, lessons learned for metropolis epidemics prevention

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  • Site-wide: 3,721
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  • Site-wide: 19,724
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  • Site-wide: 10,120

Binary and analog variation of synapses between cortical pyramidal neurons

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  • Site-wide: 3,967
  • In neuroscience: 361
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  • Site-wide: 92,061

A single dose SARS-CoV-2 simulating particle vaccine induces potent neutralizing activities

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  • Site-wide: 4,281
  • In bioengineering: 52
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  • Site-wide: 12,594
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  • Site-wide: 3,490

Cell specific eQTL analysis without sorting cells

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  • Site-wide: 6,480
  • In genetics: 327
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  • Site-wide: 97,774

Antibody dynamics to SARS-CoV-2 in Asymptomatic and Mild COVID-19 patients

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  • Site-wide: 7,231
  • In infectious diseases: 889
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  • Site-wide: 22,542

Multiscale and multimodal reconstruction of cortical structure and function

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  • Site-wide: 7,771
  • In neuroscience: 827
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  • Site-wide: 8,529

GeNets: A unified web platform for network-based analyses of genomic data

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  • Site-wide: 8,752
  • In genomics: 1,013
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  • Site-wide: 102,658

Allele-Specific Quantification of Structural Variations in Cancer Genomes

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  • Site-wide: 9,205
  • In bioinformatics: 1,159
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  • Site-wide: 68,146

An epigenetic landscape governs early fate decision in cellular aging

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  • Site-wide: 12,710
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  • Site-wide: 74,010

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption

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  • Site-wide: 13,341
  • In genomics: 1,466
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  • Site-wide: 16,049

Chandelier cell anatomy and function reveal a variably distributed but common signal

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  • Site-wide: 15,942
  • In neuroscience: 2,002
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  • Site-wide: 6,544
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  • Site-wide: 7,926

Natural Variation of OsLG3 Controls Drought Stress Tolerance in Rice by Inducing ROS Scavenging

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  • Site-wide: 19,086
  • In plant biology: 309
• Year to date:
  • Site-wide: 56,308
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  • Site-wide: 38,733

The N-cadherin interactome in primary cardiomyocytes as defined by quantitative proximity proteomics.

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  • Site-wide: 25,196
  • In cell biology: 942
• Year to date:
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  • Site-wide: 62,726

Biological variation in the sizes, shapes and locations of visual cortical areas in the mouse

• Downloaded 759 times
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  • Site-wide: 26,860
  • In neuroscience: 3,657
• Year to date:
  • Site-wide: 60,183
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  • Site-wide: 40,299

Recurrently deregulated lncRNAs associated with HCC tumorigenesis and metastasis revealed by genomic, epigenomic and transcriptomic profiling in paired primary tumor and PVTT samples

• Downloaded 749 times
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  • Site-wide: 27,409
  • In genomics: 2,588
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  • Site-wide: 75,969

Multi-generational silencing dynamics control cell aging

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  • Site-wide: 27,539
  • In systems biology: 627
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  • Site-wide: 114,955

An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

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  • Site-wide: 28,746
  • In systems biology: 661
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  • Site-wide: 80,045

Identification of PDE6D as a potential target of sorafenib via PROTAC technology

• Downloaded 704 times
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  • Site-wide: 29,894
  • In biochemistry: 734
• Year to date:
  • Site-wide: 7,025
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  • Site-wide: 8,293

Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

• Downloaded 704 times
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  • Site-wide: 29,896
  • In infectious diseases: 1,768
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  • Site-wide: None
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  • Site-wide: 31,799

Preliminary evaluation of the safety and efficacy of oral human antimicrobial peptide LL-37 in the treatment of patients of COVID-19, a small-scale, single-arm, exploratory safety study

• Downloaded 699 times
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  • Site-wide: 30,189
  • In infectious diseases: 1,781
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  • Site-wide: None
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  • Site-wide: 27,775

Linear epitope landscape of SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

• Downloaded 667 times
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  • Site-wide: 32,143
  • In infectious diseases: 1,834
• Year to date:
  • Site-wide: 49,784
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  • Site-wide: 11,463

Antibody binding epitope Mapping (AbMap) of hundred antibodies in a single run

• Downloaded 633 times
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  • Site-wide: 34,367
  • In immunology: 916
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  • Site-wide: 12,003
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  • Site-wide: 14,195

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

• Downloaded 584 times
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  • Site-wide: 38,074
  • In immunology: 1,006
• Year to date:
  • Site-wide: 24,987
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  • Site-wide: 18,983

Cycloserine for Treatment of Multidrug-Resistant Tuberculosis in China: A Retrospective Observational Study

• Downloaded 562 times
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  • Site-wide: 39,959
  • In microbiology: 2,409
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  • Site-wide: None
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  • Site-wide: 76,233

Epigenetic Reprogramming of Tissue-Specific Transcription Promotes Metastasis

• Downloaded 555 times
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  • Site-wide: 40,587
  • In cancer biology: 1,148
• Year to date:
  • Site-wide: 69,536
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  • Site-wide: 45,368

Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons

• Downloaded 540 times
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  • Site-wide: 42,025
  • In neuroscience: 6,118
• Year to date:
  • Site-wide: 65,338
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  • Site-wide: 67,839

From Community Acquired Pneumonia to COVID-19: A Deep Learning Based Method for Quantitative Analysis of COVID-19 on thick-section CT Scans

• Downloaded 508 times
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  • Site-wide: 45,247
  • In radiology and imaging: 71
• Year to date:
  • Site-wide: 22,285
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  • Site-wide: 31,764

Gender differences in attitudes toward death among Chinese university students: A survey in hunan and Heilongjiang province

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  • Site-wide: 46,991
  • In scientific communication and education: 288
• Year to date:
  • Site-wide: 44,108
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  • Site-wide: 26,970

Electrospun Ag-doped SnO2 hollow nanofibers with high antibacterial activity

• Downloaded 490 times
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  • Site-wide: 47,092
  • In biochemistry: 1,236
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  • Site-wide: None
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  • Site-wide: 66,143

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

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  • Site-wide: 48,167
  • In biophysics: 1,685
• Year to date:
  • Site-wide: 69,807
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  • Site-wide: 47,594

RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in macrophages

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  • Site-wide: 48,384
  • In immunology: 1,295
• Year to date:
  • Site-wide: 22,712
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  • Site-wide: 17,141

Vinculin anchors contractile actin to the cardiomyocyte adherens junction

• Downloaded 478 times
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  • Site-wide: 48,506
  • In cell biology: 2,123
• Year to date:
  • Site-wide: 41,416
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  • Site-wide: 77,254

Ultra-fast and accurate motif finding in large ChIP-seq datasets reveals transcription factor binding patterns

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  • Site-wide: 52,825
  • In bioinformatics: 5,455
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  • Site-wide: 66,325
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  • Site-wide: 90,723

A label-free approach to detect ligand binding to cell surface proteins in real time

• Downloaded 367 times
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  • Site-wide: 63,604
  • In biophysics: 2,350
• Year to date:
  • Site-wide: 63,131
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  • Site-wide: 110,587

SLFL Genes Participate in the Ubiquitination and Degradation of S-RNase in Self-Compatible Chinese Peach

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  • Site-wide: 66,726
  • In molecular biology: 1,990
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  • Site-wide: 56,534

Variable sensitivity to DNA damaging chemotherapeutic modulated by cell type-dependent bimodal p53 dynamics

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  • Site-wide: 68,187
  • In systems biology: 1,692
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  • Site-wide: 116,960

bHLH11 negatively regulates Fe homeostasis by its EAR motifs recruiting corepressors in Arabidopsis

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  • Site-wide: 75,891
  • In plant biology: 2,038
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  • Site-wide: 104,029

Progressive and accurate assembly of multi-domain protein structures from cryo-EM density maps

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  • Site-wide: 76,399
  • In bioinformatics: 7,058
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  • Site-wide: 93,927

Microplate Assay for Denatured Collagen using Collagen Hybridizing Peptides

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  • Site-wide: 77,254
  • In bioengineering: 1,445
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  • Site-wide: 68,899
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  • Site-wide: 45,257

Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity

• Downloaded 284 times
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  • Site-wide: 78,251
  • In bioinformatics: 7,189
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  • Site-wide: 17,222

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution

• Downloaded 263 times
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  • Site-wide: 82,603
  • In epidemiology: 3,315
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  • Site-wide: 13,219
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  • Site-wide: 31,391

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

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  • Site-wide: 85,325
  • In genetics: 3,973
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  • Site-wide: 23,237

RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases

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  • Site-wide: 85,933
  • In neuroscience: 13,399
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Evolutionary rate covariation analysis of E-cadherin identifies Raskol as regulator of cell adhesion and actin dynamics in Drosophila

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  • Site-wide: 86,515
  • In genetics: 4,023
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  • Site-wide: 99,952

FER-LIKE FE DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (OsFIT) interacts with OsIRO2 to regulate iron homeostasis

• Downloaded 242 times
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  • Site-wide: 86,914
  • In plant biology: 2,340
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  • Site-wide: None
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  • Site-wide: 105,920

Reconstructing species evolutionary trees using the numerical features of microRNA

• Downloaded 239 times
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  • Site-wide: 87,613
  • In bioinformatics: 7,798
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  • Site-wide: 31,349
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  • Site-wide: 92,288

Rapid detection of cytochrome cd1-containing nitrite reductase encoding gene nirS with loop-mediated isothermal amplification assay

• Downloaded 201 times
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  • Site-wide: 95,482
  • In microbiology: 6,986
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  • Site-wide: 32,485
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  • Site-wide: 58,542

SARS-CoV-2 antibody signatures for predicting the outcome of COVID-19

• Downloaded 201 times
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  • Site-wide: 95,465
  • In infectious diseases: 3,164
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  • Site-wide: None
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  • Site-wide: 17,872

Systematic evaluation of SARS-CoV-2 spike protein derived peptides for diagnosis of COVID-19 patients

• Downloaded 197 times
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  • Site-wide: 96,409
  • In public and global health: 948
• Year to date:
  • Site-wide: 33,172
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  • Site-wide: 19,643

Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance

• Downloaded 185 times
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  • Site-wide: 98,898
  • In bioengineering: 1,933
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  • Site-wide: 12,981
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  • Site-wide: 23,859

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response

• Downloaded 162 times
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  • Site-wide: 103,450
  • In molecular biology: 3,127
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  • Site-wide: 44,010
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  • Site-wide: 32,868

Cytochrome OmcS is not essential for long-range electron transport in Geobacter sulfurreducens strain KN400

• Downloaded 155 times
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  • Site-wide: 104,705
  • In microbiology: 7,834
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  • Site-wide: 34,218
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  • Site-wide: 32,857

Discovery Function Labels Based On Numerical Features Of MicroRNA Found In Plant

• Downloaded 151 times
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  • Site-wide: 105,420
  • In bioinformatics: 8,868
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  • Site-wide: 38,758
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  • Site-wide: 99,839

A combined microphysiological-computational omics approach in dietary protein evaluation

• Downloaded 146 times
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  • Site-wide: 106,351
  • In bioengineering: 2,108
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  • Site-wide: 24,788
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  • Site-wide: 39,738

Exploration of target spaces in the human genome for protein and peptide drugs

• Downloaded 142 times
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  • Site-wide: 107,110
  • In bioinformatics: 8,952
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  • Site-wide: None
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  • Site-wide: 111,701

Discovering Differences and Similarities among Species Based on Numeric Features of microRNAs

• Downloaded 137 times
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  • Site-wide: 108,018
  • In bioinformatics: 8,999
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  • Site-wide: 116,315

Deducing high-accuracy protein contact-maps from a triplet of coevolutionary matrices through deep residual convolutional networks

• Downloaded 134 times
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  • Site-wide: 108,565
  • In bioinformatics: 9,027
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  • Site-wide: 76,113

MpsLDA-ProSVM: predicting multi-label protein subcellular localization by wMLDAe dimensionality reduction and ProSVM classifier

• Downloaded 130 times
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  • Site-wide: 109,218
  • In bioinformatics: 9,064
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  • Site-wide: 34,850
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  • Site-wide: 66,294

A new strategy for selection of crop cultivated varieties based on yield factors driving and meteorological prediction

• Downloaded 116 times
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  • Site-wide: 111,726
  • In plant biology: 3,114
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  • Site-wide: 64,490
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  • Site-wide: 79,110

Protein Surface Printer for Exploring Protein Domains

• Downloaded 94 times
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  • Site-wide: 115,351
  • In bioinformatics: 9,404
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  • Site-wide: None
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  • Site-wide: 113,579

Reverse-transcription recombinase-aided amplification assay for H5 subtype avian influenza virus

• Downloaded 74 times
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  • Site-wide: 118,434
  • In molecular biology: 3,616
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  • Site-wide: 41,324

Collagen induced inflammations

• Downloaded 66 times
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  • Site-wide: 119,610
  • In immunology: 3,383
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  • Site-wide: 18,955
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  • Site-wide: 46,402