Author: Ian J Deary

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

• Downloaded 9,364 times
• Download rankings, all-time:
  • Site-wide: 821
  • In genetics: 25
• Year to date:
  • Site-wide: 24,155
• Since beginning of last month:
  • Site-wide: 27,279

The genetic architecture of the human cerebral cortex

• Downloaded 7,906 times
• Download rankings, all-time:
  • Site-wide: 1,016
  • In genetics: 30
• Year to date:
  • Site-wide: 17,771
• Since beginning of last month:
  • Site-wide: None

Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

• Downloaded 3,073 times
• Download rankings, all-time:
  • Site-wide: 3,754
  • In genetics: 166
• Year to date:
  • Site-wide: 36,168
• Since beginning of last month:
  • Site-wide: 38,801

Genetic analysis identifies molecular systems and biological pathways associated with household income

• Downloaded 2,704 times
• Download rankings, all-time:
  • Site-wide: 4,490
  • In genetics: 207
• Year to date:
  • Site-wide: 80,228
• Since beginning of last month:
  • Site-wide: 53,397

Genome-wide association study identifies 48 common genetic variants associated with handedness

• Downloaded 2,526 times
• Download rankings, all-time:
  • Site-wide: 4,960
  • In genetics: 229
• Year to date:
  • Site-wide: 18,021
• Since beginning of last month:
  • Site-wide: 18,917

Molecular genetic contributions to self-rated health

• Downloaded 2,213 times
• Download rankings, all-time:
  • Site-wide: 6,040
  • In genetics: 292
• Year to date:
  • Site-wide: 54,938
• Since beginning of last month:
  • Site-wide: 53,891

Genetic “General Intelligence,” Objectively Determined and Measured

• Downloaded 2,119 times
• Download rankings, all-time:
  • Site-wide: 6,422
  • In genetics: 318
• Year to date:
  • Site-wide: 10,234
• Since beginning of last month:
  • Site-wide: 8,097

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112,117).

• Downloaded 2,035 times
• Download rankings, all-time:
  • Site-wide: 6,796
  • In genetics: 335
• Year to date:
  • Site-wide: 93,024
• Since beginning of last month:
  • Site-wide: 55,562

GWAS on family history of Alzheimer's disease

• Downloaded 1,972 times
• Download rankings, all-time:
  • Site-wide: 7,114
  • In genetics: 345
• Year to date:
  • Site-wide: 62,011
• Since beginning of last month:
  • Site-wide: 34,984

Genetic Prediction of Male Pattern Baldness

• Downloaded 1,783 times
• Download rankings, all-time:
  • Site-wide: 8,303
  • In genetics: 403
• Year to date:
  • Site-wide: 42,805
• Since beginning of last month:
  • Site-wide: 37,466

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

• Downloaded 1,700 times
• Download rankings, all-time:
  • Site-wide: 8,957
  • In genetics: 444
• Year to date:
  • Site-wide: 100,342
• Since beginning of last month:
  • Site-wide: None

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)

• Downloaded 1,631 times
• Download rankings, all-time:
  • Site-wide: 9,524
  • In neuroscience: 1,032
• Year to date:
  • Site-wide: 65,483
• Since beginning of last month:
  • Site-wide: 94,473

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

• Downloaded 1,574 times
• Download rankings, all-time:
  • Site-wide: 10,043
  • In genomics: 1,110
• Year to date:
  • Site-wide: 51,656
• Since beginning of last month:
  • Site-wide: 39,595

Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium

• Downloaded 1,461 times
• Download rankings, all-time:
  • Site-wide: 11,163
  • In neuroscience: 1,265
• Year to date:
  • Site-wide: 67,258
• Since beginning of last month:
  • Site-wide: 89,613

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

• Downloaded 1,406 times
• Download rankings, all-time:
  • Site-wide: 11,841
  • In genetics: 595
• Year to date:
  • Site-wide: 28,356
• Since beginning of last month:
  • Site-wide: 20,366

OSCA: a tool for omic-data-based complex trait analysis

• Downloaded 1,109 times
• Download rankings, all-time:
  • Site-wide: 16,943
  • In bioinformatics: 2,067
• Year to date:
  • Site-wide: 92,432
• Since beginning of last month:
  • Site-wide: 98,100

Subcortical volume and white matter integrity abnormalities in major depressive disorder: findings from UK Biobank imaging data

• Downloaded 1,073 times
• Download rankings, all-time:
  • Site-wide: 17,762
  • In neuroscience: 2,241
• Year to date:
  • Site-wide: 94,452
• Since beginning of last month:
  • Site-wide: 80,881

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

• Downloaded 1,054 times
• Download rankings, all-time:
  • Site-wide: 18,242
  • In genetics: 918
• Year to date:
  • Site-wide: 5,475
• Since beginning of last month:
  • Site-wide: 4,527

Identification of 55,000 Replicated DNA Methylation QTL

• Downloaded 1,038 times
• Download rankings, all-time:
  • Site-wide: 18,698
  • In genomics: 1,924
• Year to date:
  • Site-wide: 73,682
• Since beginning of last month:
  • Site-wide: 67,650

Genome wide analysis of gene dosage in 24,092 individuals shows that 10,000 genes modulate cognitive ability

• Downloaded 1,011 times
• Download rankings, all-time:
  • Site-wide: 19,472
  • In genetics: 970
• Year to date:
  • Site-wide: 9,118
• Since beginning of last month:
  • Site-wide: 15,055

An epigenome-wide association study of educational attainment (n = 10,767)

• Downloaded 984 times
• Download rankings, all-time:
  • Site-wide: 20,194
  • In genetics: 1,000
• Year to date:
  • Site-wide: 50,036
• Since beginning of last month:
  • Site-wide: 46,314

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank

• Downloaded 860 times
• Download rankings, all-time:
  • Site-wide: 24,524
  • In genetics: 1,217
• Year to date:
  • Site-wide: 94,084
• Since beginning of last month:
  • Site-wide: None

GWAS of epigenetic ageing rates in blood reveals a critical role for TERT

• Downloaded 815 times
• Download rankings, all-time:
  • Site-wide: 26,431
  • In genetics: 1,308
• Year to date:
  • Site-wide: 105,485
• Since beginning of last month:
  • Site-wide: 95,197

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

• Downloaded 810 times
• Download rankings, all-time:
  • Site-wide: 26,638
  • In genomics: 2,517
• Year to date:
  • Site-wide: 55,295
• Since beginning of last month:
  • Site-wide: 39,170

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

• Downloaded 790 times
• Download rankings, all-time:
  • Site-wide: 27,593
  • In genetics: 1,367
• Year to date:
  • Site-wide: 81,755
• Since beginning of last month:
  • Site-wide: 44,617

Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways

• Downloaded 750 times
• Download rankings, all-time:
  • Site-wide: 29,693
  • In genetics: 1,468
• Year to date:
  • Site-wide: 110,066
• Since beginning of last month:
  • Site-wide: None

Factors associated with sharing email information and mental health survey participation in large population cohorts

• Downloaded 745 times
• Download rankings, all-time:
  • Site-wide: 29,903
  • In genetics: 1,479
• Year to date:
  • Site-wide: 71,557
• Since beginning of last month:
  • Site-wide: 51,667

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

• Downloaded 724 times
• Download rankings, all-time:
  • Site-wide: 31,183
  • In genomics: 2,825
• Year to date:
  • Site-wide: 16,433
• Since beginning of last month:
  • Site-wide: 13,442

Genetic contributions to self-reported tiredness

• Downloaded 712 times
• Download rankings, all-time:
  • Site-wide: 31,890
  • In genetics: 1,581
• Year to date:
  • Site-wide: 33,291
• Since beginning of last month:
  • Site-wide: 46,831

Partial derivatives meta-analysis: pooled analyses when individual participant data cannot be shared

• Downloaded 709 times
• Download rankings, all-time:
  • Site-wide: 32,083
  • In bioinformatics: 3,644
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

• Downloaded 701 times
• Download rankings, all-time:
  • Site-wide: 32,583
  • In genomics: 2,909
• Year to date:
  • Site-wide: 112,577
• Since beginning of last month:
  • Site-wide: 96,375

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

• Downloaded 602 times
• Download rankings, all-time:
  • Site-wide: 39,766
  • In genetic and genomic medicine: 113
• Year to date:
  • Site-wide: 8,564
• Since beginning of last month:
  • Site-wide: 13,580

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

• Downloaded 576 times
• Download rankings, all-time:
  • Site-wide: 42,000
  • In genetics: 2,013
• Year to date:
  • Site-wide: 87,899
• Since beginning of last month:
  • Site-wide: 81,231

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank

• Downloaded 565 times
• Download rankings, all-time:
  • Site-wide: 43,075
  • In genetics: 2,074
• Year to date:
  • Site-wide: 87,492
• Since beginning of last month:
  • Site-wide: 99,531

DNA methylation age acceleration and risk factors for Alzheimer's disease

• Downloaded 560 times
• Download rankings, all-time:
  • Site-wide: 43,494
  • In genomics: 3,574
• Year to date:
  • Site-wide: 111,064
• Since beginning of last month:
  • Site-wide: 93,477

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

• Downloaded 557 times
• Download rankings, all-time:
  • Site-wide: 43,859
  • In neuroscience: 6,402
• Year to date:
  • Site-wide: 39,630
• Since beginning of last month:
  • Site-wide: 30,885

Age-related clonal haemopoiesis is associated with increased epigenetic age

• Downloaded 528 times
• Download rankings, all-time:
  • Site-wide: 46,744
  • In bioinformatics: 4,930
• Year to date:
  • Site-wide: 120,341
• Since beginning of last month:
  • Site-wide: 95,305

Accelerated Epigenetic Ageing in Major Depressive Disorder

• Downloaded 525 times
• Download rankings, all-time:
  • Site-wide: 47,072
  • In genomics: 3,796
• Year to date:
  • Site-wide: 80,735
• Since beginning of last month:
  • Site-wide: 74,343

Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution

• Downloaded 509 times
• Download rankings, all-time:
  • Site-wide: 48,723
  • In genomics: 3,881
• Year to date:
  • Site-wide: 119,748
• Since beginning of last month:
  • Site-wide: None

The effect of network thresholding and weighting on structural brain networks in the UK Biobank

• Downloaded 489 times
• Download rankings, all-time:
  • Site-wide: 51,148
  • In neuroscience: 7,649
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort 1936.

• Downloaded 488 times
• Download rankings, all-time:
  • Site-wide: 51,235
  • In epidemiology: 2,246
• Year to date:
  • Site-wide: 108,161
• Since beginning of last month:
  • Site-wide: 89,553

Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions

• Downloaded 484 times
• Download rankings, all-time:
  • Site-wide: 51,701
  • In genomics: 4,054
• Year to date:
  • Site-wide: 89,482
• Since beginning of last month:
  • Site-wide: 83,628

Polygenic predictors of age-related decline in cognitive ability

• Downloaded 479 times
• Download rankings, all-time:
  • Site-wide: 52,360
  • In genomics: 4,081
• Year to date:
  • Site-wide: 112,406
• Since beginning of last month:
  • Site-wide: 96,183

Genetic contributions to trail making test performance in UK Biobank

• Downloaded 456 times
• Download rankings, all-time:
  • Site-wide: 55,257
  • In genetics: 2,615
• Year to date:
  • Site-wide: 109,978
• Since beginning of last month:
  • Site-wide: 82,360

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

• Downloaded 449 times
• Download rankings, all-time:
  • Site-wide: 56,171
  • In genomics: 4,270
• Year to date:
  • Site-wide: 89,512
• Since beginning of last month:
  • Site-wide: 86,981

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

• Downloaded 432 times
• Download rankings, all-time:
  • Site-wide: 58,478
  • In neuroscience: 8,869
• Year to date:
  • Site-wide: 111,385
• Since beginning of last month:
  • Site-wide: 92,931

Birth weight associations with psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

• Downloaded 425 times
• Download rankings, all-time:
  • Site-wide: 59,399
  • In genomics: 4,417
• Year to date:
  • Site-wide: 102,527
• Since beginning of last month:
  • Site-wide: 82,035

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism

• Downloaded 416 times
• Download rankings, all-time:
  • Site-wide: 60,722
  • In genetics: 2,875
• Year to date:
  • Site-wide: 112,143
• Since beginning of last month:
  • Site-wide: 82,510

Genetic correlations between pain phenotypes and depression and neuroticism

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 62,339
  • In genetics: 2,944
• Year to date:
  • Site-wide: 98,407
• Since beginning of last month:
  • Site-wide: 61,340

Childhood intelligence attenuates the association between biological ageing and health outcomes in later life

• Downloaded 406 times
• Download rankings, all-time:
  • Site-wide: 62,357
  • In genomics: 4,547
• Year to date:
  • Site-wide: 113,785
• Since beginning of last month:
  • Site-wide: 92,598

Genetic and epigenetic architectures of neurological protein biomarkers in the Lothian Birth Cohort 1936

• Downloaded 383 times
• Download rankings, all-time:
  • Site-wide: 65,897
  • In neuroscience: 10,078
• Year to date:
  • Site-wide: 112,783
• Since beginning of last month:
  • Site-wide: 91,057

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 72,961
  • In genetics: 3,401
• Year to date:
  • Site-wide: 120,640
• Since beginning of last month:
  • Site-wide: None

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

• Downloaded 341 times
• Download rankings, all-time:
  • Site-wide: 72,888
  • In genetics: 3,399
• Year to date:
  • Site-wide: 112,517
• Since beginning of last month:
  • Site-wide: 93,887

Enhanced prediction of cognitive function using aging-sensitive networks within the human structural connectome

• Downloaded 340 times
• Download rankings, all-time:
  • Site-wide: 73,089
  • In neuroscience: 11,275
• Year to date:
  • Site-wide: 96,302
• Since beginning of last month:
  • Site-wide: 95,061

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

• Downloaded 338 times
• Download rankings, all-time:
  • Site-wide: 73,554
  • In genetics: 3,427
• Year to date:
  • Site-wide: 63,855
• Since beginning of last month:
  • Site-wide: 68,792

Genetic contributions to health literacy

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 74,011
  • In epidemiology: 3,067
• Year to date:
  • Site-wide: 107,075
• Since beginning of last month:
  • Site-wide: 92,652

Age-related changes of Peak width Skeletonized Mean Diffusivity (PSMD) across the adult life span: a multi-cohort study

• Downloaded 333 times
• Download rankings, all-time:
  • Site-wide: 74,390
  • In neuroscience: 11,484
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: None

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell counts and epigenetic ageing

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 83,566
  • In epidemiology: 3,425
• Year to date:
  • Site-wide: 100,940
• Since beginning of last month:
  • Site-wide: 53,275

Epigenetic signatures of starting and stopping smoking

• Downloaded 286 times
• Download rankings, all-time:
  • Site-wide: 83,641
  • In genomics: 5,399
• Year to date:
  • Site-wide: 114,218
• Since beginning of last month:
  • Site-wide: 79,403

Association of Facial Aging with DNA Methylation and Epigenetic Age Predictions

• Downloaded 285 times
• Download rankings, all-time:
  • Site-wide: 83,824
  • In genetics: 3,847
• Year to date:
  • Site-wide: 120,460
• Since beginning of last month:
  • Site-wide: None

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

• Downloaded 269 times
• Download rankings, all-time:
  • Site-wide: 87,221
  • In cell biology: 4,064
• Year to date:
  • Site-wide: 72,257
• Since beginning of last month:
  • Site-wide: 56,566

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

• Downloaded 223 times
• Download rankings, all-time:
  • Site-wide: 97,140
  • In neuroscience: 15,225
• Year to date:
  • Site-wide: 117,779
• Since beginning of last month:
  • Site-wide: 99,646

Creating and validating a DNA methylation-based proxy for Interleukin-6

• Downloaded 218 times
• Download rankings, all-time:
  • Site-wide: 98,201
  • In genetic and genomic medicine: 368
• Year to date:
  • Site-wide: 47,886
• Since beginning of last month:
  • Site-wide: 87,437

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

• Downloaded 112 times
• Download rankings, all-time:
  • Site-wide: 119,374
  • In neuroscience: 18,515
• Year to date:
  • Site-wide: 103,175
• Since beginning of last month:
  • Site-wide: 102,329