Author: Lin Zhang

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Preprints

Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study

• Downloaded 37,685 times
• Download rankings, all-time:
  • Site-wide: 273
  • In rheumatology: 1
• Year to date:
  • Site-wide: 13,610
• Since beginning of last month:
  • Site-wide: 6,924

An international characterisation of patients hospitalised with COVID-19 and a comparison with those previously hospitalised with influenza

• Downloaded 6,029 times
• Download rankings, all-time:
  • Site-wide: 2,713
  • In infectious diseases: 711
• Year to date:
  • Site-wide: 11,824
• Since beginning of last month:
  • Site-wide: 30,001

Retrospective Analysis of Clinical Features in 101 Death Cases with COVID-19

• Downloaded 5,771 times
• Download rankings, all-time:
  • Site-wide: 2,867
  • In intensive care and critical care medicine: 17
• Year to date:
  • Site-wide: 66,388
• Since beginning of last month:
  • Site-wide: 34,406

Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network

• Downloaded 3,230 times
• Download rankings, all-time:
  • Site-wide: 6,578
  • In health informatics: 36
• Year to date:
  • Site-wide: 47,481
• Since beginning of last month:
  • Site-wide: 30,390

Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study

• Downloaded 2,438 times
• Download rankings, all-time:
  • Site-wide: 9,950
  • In epidemiology: 807
• Year to date:
  • Site-wide: 9,710
• Since beginning of last month:
  • Site-wide: 10,488

Integrated Proteogenomic Deep Sequencing and Analytics Accurately Identify Non-Canonical Peptides in Tumor Immunopeptidomes

• Downloaded 2,158 times
• Download rankings, all-time:
  • Site-wide: 11,982
  • In cancer biology: 227
• Year to date:
  • Site-wide: 75,535
• Since beginning of last month:
  • Site-wide: 81,000

Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin

• Downloaded 2,155 times
• Download rankings, all-time:
  • Site-wide: 12,005
  • In biochemistry: 249
• Year to date:
  • Site-wide: 3,584
• Since beginning of last month:
  • Site-wide: 11,550

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells

• Downloaded 2,068 times
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  • Site-wide: 12,765
  • In synthetic biology: 142
• Year to date:
  • Site-wide: 68,059
• Since beginning of last month:
  • Site-wide: 26,835

Screening for functional circular RNAs using the CRISPR-Cas13 system

• Downloaded 1,977 times
• Download rankings, all-time:
  • Site-wide: 13,687
  • In molecular biology: 345
• Year to date:
  • Site-wide: 29,369
• Since beginning of last month:
  • Site-wide: 30,096

Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study

• Downloaded 1,870 times
• Download rankings, all-time:
  • Site-wide: 14,887
  • In cardiovascular medicine: 23
• Year to date:
  • Site-wide: 87,952
• Since beginning of last month:
  • Site-wide: 53,553

Characteristics, outcomes, and mortality amongst 133,589 patients with prevalent autoimmune diseases diagnosed with, and 48,418 hospitalised for COVID-19: a multinational distributed network cohort analysis

• Downloaded 1,589 times
• Download rankings, all-time:
  • Site-wide: 19,206
  • In epidemiology: 1,281
• Year to date:
  • Site-wide: 93,008
• Since beginning of last month:
  • Site-wide: 21,904

Risk of depression, suicidal ideation, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multi-national network cohort study

• Downloaded 1,545 times
• Download rankings, all-time:
  • Site-wide: 20,077
  • In epidemiology: 1,312
• Year to date:
  • Site-wide: 49,650
• Since beginning of last month:
  • Site-wide: 39,595

A case of SARS-CoV-2 carrier for 32 days with several times false negative nucleic acid tests

• Downloaded 1,380 times
• Download rankings, all-time:
  • Site-wide: 24,086
  • In infectious diseases: 2,556
• Year to date:
  • Site-wide: 67,608
• Since beginning of last month:
  • Site-wide: 76,167

Heterogeneity and temporal variation in the management of COVID-19: a multinational drug utilization study including 71,921 hospitalized patients from China, South Korea, Spain, and the United States of America

• Downloaded 1,273 times
• Download rankings, all-time:
  • Site-wide: 27,428
  • In epidemiology: 1,612
• Year to date:
  • Site-wide: 48,753
• Since beginning of last month:
  • Site-wide: 50,189

The effect of anti-SARS-CoV-2 monoclonal antibody, bamlanivimab, on endogenous immune response to COVID-19 vaccination

• Downloaded 1,214 times
• Download rankings, all-time:
  • Site-wide: 29,529
  • In infectious diseases: 2,851
• Year to date:
  • Site-wide: 23,548
• Since beginning of last month:
  • Site-wide: 26,753

Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 240,392 patients hospitalized with COVID-19 in the United States

• Downloaded 1,130 times
• Download rankings, all-time:
  • Site-wide: 33,073
  • In infectious diseases: 3,007
• Year to date:
  • Site-wide: 69,277
• Since beginning of last month:
  • Site-wide: 56,667

simATAC: A single-cell ATAC-seq simulation framework

• Downloaded 1,122 times
• Download rankings, all-time:
  • Site-wide: 33,434
  • In bioinformatics: 3,536
• Year to date:
  • Site-wide: 84,977
• Since beginning of last month:
  • Site-wide: 132,234

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

• Downloaded 971 times
• Download rankings, all-time:
  • Site-wide: 41,756
  • In immunology: 1,503
• Year to date:
  • Site-wide: 12,641
• Since beginning of last month:
  • Site-wide: 8,390

Outcomes of ureteroscopy and internal ureteral stent for pregnancy with urolithiasis: a systematic review and meta-analysis

• Downloaded 939 times
• Download rankings, all-time:
  • Site-wide: 43,939
  • In urology: 15
• Year to date:
  • Site-wide: 129,445
• Since beginning of last month:
  • Site-wide: 44,910

Systematic evaluation of parameters for genome-scale metabolic models of cultured mammalian cells

• Downloaded 878 times
• Download rankings, all-time:
  • Site-wide: 48,764
  • In systems biology: 969
• Year to date:
  • Site-wide: 45,974
• Since beginning of last month:
  • Site-wide: 53,200

Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States

• Downloaded 866 times
• Download rankings, all-time:
  • Site-wide: 49,793
  • In infectious diseases: 3,768
• Year to date:
  • Site-wide: 130,090
• Since beginning of last month:
  • Site-wide: 85,664

A single-cell atlas of bobtail squid visual and nervous system highlights molecular principles of convergent evolution

• Downloaded 826 times
• Download rankings, all-time:
  • Site-wide: 53,519
  • In evolutionary biology: 2,461
• Year to date:
  • Site-wide: 4,648
• Since beginning of last month:
  • Site-wide: 14,543

One Cell At a Time: A Unified Framework to Integrate and Analyze Single-cell RNA-seq Data

• Downloaded 812 times
• Download rankings, all-time:
  • Site-wide: 54,850
  • In genomics: 3,904
• Year to date:
  • Site-wide: 183,780
• Since beginning of last month:
  • Site-wide: 114,156

The differential impacts of dataset imbalance in single-cell data integration

• Downloaded 802 times
• Download rankings, all-time:
  • Site-wide: 55,934
  • In bioinformatics: 6,618
• Year to date:
  • Site-wide: 11,181
• Since beginning of last month:
  • Site-wide: 2,214

Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom

• Downloaded 801 times
• Download rankings, all-time:
  • Site-wide: 55,959
  • In epidemiology: 2,724
• Year to date:
  • Site-wide: 129,707
• Since beginning of last month:
  • Site-wide: 110,572

Microbial Species Abundance Distributions Guide Human Population Size Estimation from Sewage Microbiomes

• Downloaded 773 times
• Download rankings, all-time:
  • Site-wide: 59,034
  • In bioinformatics: 5,777
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 85,350

Can we trust the prediction model? Demonstrating the importance of external validation by investigating the COVID-19 Vulnerability (C-19) Index across an international network of observational healthcare datasets

• Downloaded 773 times
• Download rankings, all-time:
  • Site-wide: 59,002
  • In health informatics: 271
• Year to date:
  • Site-wide: 156,155
• Since beginning of last month:
  • Site-wide: 128,775

Structure of the GOLD-domain seven-transmembrane helix protein family member TMEM87A

• Downloaded 770 times
• Download rankings, all-time:
  • Site-wide: 59,355
  • In biophysics: 2,070
• Year to date:
  • Site-wide: 7,714
• Since beginning of last month:
  • Site-wide: 15,665

Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: A multicenter cohort study

• Downloaded 751 times
• Download rankings, all-time:
  • Site-wide: 61,593
  • In infectious diseases: 4,169
• Year to date:
  • Site-wide: 161,193
• Since beginning of last month:
  • Site-wide: 125,263

Clinical characteristics, symptoms, management and health outcomes in 8,598 pregnant women diagnosed with COVID-19 compared to 27,510 with seasonal influenza in France, Spain and the US: a network cohort analysis

• Downloaded 728 times
• Download rankings, all-time:
  • Site-wide: 64,513
  • In infectious diseases: 4,272
• Year to date:
  • Site-wide: 89,999
• Since beginning of last month:
  • Site-wide: 156,190

CytoGPS: A Web-Enabled Karyotype Analysis Tool for Cytogenetics

• Downloaded 711 times
• Download rankings, all-time:
  • Site-wide: 66,736
  • In bioinformatics: 6,293
• Year to date:
  • Site-wide: 169,251
• Since beginning of last month:
  • Site-wide: 207,552

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells

• Downloaded 673 times
• Download rankings, all-time:
  • Site-wide: 72,009
  • In immunology: 2,355
• Year to date:
  • Site-wide: 163,545
• Since beginning of last month:
  • Site-wide: 192,629

Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

• Downloaded 645 times
• Download rankings, all-time:
  • Site-wide: 76,221
  • In oncology: 154
• Year to date:
  • Site-wide: 91,005
• Since beginning of last month:
  • Site-wide: 137,717

Genomic signatures of somatic hybrid vigor due to heterokaryosis in the oomycete pathogen, Bremia lactucae.

• Downloaded 630 times
• Download rankings, all-time:
  • Site-wide: 78,648
  • In genomics: 5,128
• Year to date:
  • Site-wide: 139,983
• Since beginning of last month:
  • Site-wide: 152,905

Sub physiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells

• Downloaded 628 times
• Download rankings, all-time:
  • Site-wide: 78,918
  • In cell biology: 3,537
• Year to date:
  • Site-wide: 63,629
• Since beginning of last month:
  • Site-wide: 187,420

A Generalized Robust Allele-based Genetic Association Test

• Downloaded 559 times
• Download rankings, all-time:
  • Site-wide: 91,478
  • In genetics: 3,503
• Year to date:
  • Site-wide: 129,161
• Since beginning of last month:
  • Site-wide: 190,803

Found in translation: Microproteins are a new class of potential host cell impurity in mAb drug products

• Downloaded 546 times
• Download rankings, all-time:
  • Site-wide: 94,279
  • In genomics: 6,024
• Year to date:
  • Site-wide: 12,659
• Since beginning of last month:
  • Site-wide: 22,463

EZH2 Engages TGFβ Signaling to Promote Breast Cancer Bone Metastasis via Integrin β1-FAK Activation

• Downloaded 541 times
• Download rankings, all-time:
  • Site-wide: 95,280
  • In cancer biology: 2,872
• Year to date:
  • Site-wide: 107,966
• Since beginning of last month:
  • Site-wide: 96,198

A genome-scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary cell cultures

• Downloaded 540 times
• Download rankings, all-time:
  • Site-wide: 95,367
  • In systems biology: 2,037
• Year to date:
  • Site-wide: 30,436
• Since beginning of last month:
  • Site-wide: 30,245

Risk assessment and prediction of severe or critical illness of COVID-19 in the elderly

• Downloaded 526 times
• Download rankings, all-time:
  • Site-wide: 98,422
  • In public and global health: 1,508
• Year to date:
  • Site-wide: 88,623
• Since beginning of last month:
  • Site-wide: 188,293

Expanding the Chinese hamster ovary cell long non-coding RNA transcriptome using RNASeq

• Downloaded 524 times
• Download rankings, all-time:
  • Site-wide: 98,745
  • In cell biology: 4,663
• Year to date:
  • Site-wide: 41,812
• Since beginning of last month:
  • Site-wide: 45,796

Toxicities of PD-1/PD-L1 Inhibitors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Downloaded 521 times
• Download rankings, all-time:
  • Site-wide: 99,450
  • In oncology: 237
• Year to date:
  • Site-wide: 123,403
• Since beginning of last month:
  • Site-wide: 104,587

The Tung Tree (Vernicia Fordii) Genome Provides A Resource for Understanding Genome Evolution and Oil Improvement

• Downloaded 515 times
• Download rankings, all-time:
  • Site-wide: 100,798
  • In bioinformatics: 8,790
• Year to date:
  • Site-wide: 64,262
• Since beginning of last month:
  • Site-wide: 131,765

Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain

• Downloaded 513 times
• Download rankings, all-time:
  • Site-wide: 101,219
  • In epidemiology: 4,404
• Year to date:
  • Site-wide: 92,771
• Since beginning of last month:
  • Site-wide: 55,226

Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans

• Downloaded 508 times
• Download rankings, all-time:
  • Site-wide: 102,552
  • In genetics: 3,876
• Year to date:
  • Site-wide: 109,663
• Since beginning of last month:
  • Site-wide: 114,632

On a Unifying ‘Reverse’ Regression for Robust Association Studies and Allele Frequency Estimation with Related Individuals

• Downloaded 495 times
• Download rankings, all-time:
  • Site-wide: 105,504
  • In genetics: 3,972
• Year to date:
  • Site-wide: 171,453
• Since beginning of last month:
  • Site-wide: 205,732

AFLAP: Assembly-Free Linkage Analysis Pipeline using k-mers from whole genome sequencing data

• Downloaded 482 times
• Download rankings, all-time:
  • Site-wide: 108,497
  • In genetics: 4,110
• Year to date:
  • Site-wide: 154,399
• Since beginning of last month:
  • Site-wide: 124,040

Dissecting molecular regulatory mechanisms underlying noncoding susceptibility SNPs associated with 19 autoimmune diseases using multi-omics integrative analysis

• Downloaded 469 times
• Download rankings, all-time:
  • Site-wide: 111,748
  • In immunology: 3,550
• Year to date:
  • Site-wide: 144,264
• Since beginning of last month:
  • Site-wide: 190,046

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 467 times
• Download rankings, all-time:
  • Site-wide: 112,254
  • In genetics: 4,231
• Year to date:
  • Site-wide: 99,061
• Since beginning of last month:
  • Site-wide: 208,250

Conserving unprotected important coastal habitats in the Yellow Sea: shorebird occurrence, distribution and food resources at Lianyungang

• Downloaded 435 times
• Download rankings, all-time:
  • Site-wide: 120,320
  • In ecology: 3,287
• Year to date:
  • Site-wide: 192,657
• Since beginning of last month:
  • Site-wide: 153,548

Targeted over-expression of PPARγ in pig skeletal muscle improves oxidative fiber formation and intramuscular fat deposition

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 131,232
  • In genetics: 4,954
• Year to date:
  • Site-wide: 90,152
• Since beginning of last month:
  • Site-wide: 53,798

Nonlinear Dispersive Cell Model for Microdosimetry of Nanosecond Pulsed Electric Fields

• Downloaded 396 times
• Download rankings, all-time:
  • Site-wide: 131,327
  • In bioengineering: 2,634
• Year to date:
  • Site-wide: 191,301
• Since beginning of last month:
  • Site-wide: 181,526

Meta-analysis of exhausted CD8+ T cells from Homo sapiens and Mus musculus provides robust targets for immunotherapy

• Downloaded 390 times
• Download rankings, all-time:
  • Site-wide: 132,982
  • In bioinformatics: 11,022
• Year to date:
  • Site-wide: 35,761
• Since beginning of last month:
  • Site-wide: 24,026

Characteristics and influence of type 2 diabetes in cirrhosis ascites with spontaneous bacterial peritonitis

• Downloaded 375 times
• Download rankings, all-time:
  • Site-wide: 137,346
  • In endocrinology: 162
• Year to date:
  • Site-wide: 156,738
• Since beginning of last month:
  • Site-wide: 94,810

The rice G protein γ subunit qPE9-1 positively regulates grain-filling process by interacting with abscisic acid and auxin

• Downloaded 367 times
• Download rankings, all-time:
  • Site-wide: 139,621
  • In plant biology: 3,769
• Year to date:
  • Site-wide: 170,959
• Since beginning of last month:
  • Site-wide: 206,020

Architecture of the NADH:ferredoxin oxidoreductase RNF that drives Biological Nitrogen Fixation

• Downloaded 352 times
• Download rankings, all-time:
  • Site-wide: 144,258
  • In biochemistry: 4,406
• Year to date:
  • Site-wide: 53,669
• Since beginning of last month:
  • Site-wide: 32,577

Association Between Blood Circulating Vitamin D and Colorectal Cancer Risk in Asian Countries: A Systematic Review and Dose-Response Meta-analysis

• Downloaded 342 times
• Download rankings, all-time:
  • Site-wide: 147,387
  • In oncology: 476
• Year to date:
  • Site-wide: 161,616
• Since beginning of last month:
  • Site-wide: 191,666

Leveraging Hardy-Weinberg disequilibrium for association testing in case-control studies

• Downloaded 335 times
• Download rankings, all-time:
  • Site-wide: 149,439
  • In genetics: 5,609
• Year to date:
  • Site-wide: 66,240
• Since beginning of last month:
  • Site-wide: 45,629

Using remotely delivered Spring Forest Qigong to reduce neuropathic pain in adults with spinal cord injury: Protocol of a quasi-experimental clinical trial

• Downloaded 334 times
• Download rankings, all-time:
  • Site-wide: 149,833
  • In rehabilitation medicine and physical therapy: 201
• Year to date:
  • Site-wide: 107,108
• Since beginning of last month:
  • Site-wide: 29,032

Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine

• Downloaded 330 times
• Download rankings, all-time:
  • Site-wide: 150,907
  • In cell biology: 7,110
• Year to date:
  • Site-wide: 58,254
• Since beginning of last month:
  • Site-wide: 61,894

SBP-SITA: A sequence-based prediction tools for S-itaconation

• Downloaded 309 times
• Download rankings, all-time:
  • Site-wide: 157,181
  • In bioinformatics: 12,437
• Year to date:
  • Site-wide: 36,489
• Since beginning of last month:
  • Site-wide: 50,864

Level and duration of IgG and neutralizing antibodies to SARS-CoV-2 in children with symptomatic or asymptomatic SARS-CoV-2 infection

• Downloaded 305 times
• Download rankings, all-time:
  • Site-wide: 158,353
  • In infectious diseases: 7,152
• Year to date:
  • Site-wide: 107,431
• Since beginning of last month:
  • Site-wide: 170,970

Quantitatively Monitoring in situ Mitochondrial Thermal Dynamics by Upconversion Nanoparticles

• Downloaded 303 times
• Download rankings, all-time:
  • Site-wide: 158,955
  • In cell biology: 7,375
• Year to date:
  • Site-wide: 161,310
• Since beginning of last month:
  • Site-wide: 210,878

The endophilin curvature-sensitive motif requires electrostatic guidance to recycle synaptic vesicles in vivo

• Downloaded 287 times
• Download rankings, all-time:
  • Site-wide: 164,017
  • In cell biology: 7,614
• Year to date:
  • Site-wide: 150,200
• Since beginning of last month:
  • Site-wide: 172,216

mTORC2 mediate FLCN-induced HIF2α nuclear import and proliferation of clear cell renal cell carcinoma

• Downloaded 280 times
• Download rankings, all-time:
  • Site-wide: 165,950
  • In cell biology: 7,692
• Year to date:
  • Site-wide: 159,811
• Since beginning of last month:
  • Site-wide: 214,613

Correlation between serum 25(OH) vitamin D level and sleep quality in elderly patients with type 2 diabetes

• Downloaded 264 times
• Download rankings, all-time:
  • Site-wide: 170,710
  • In endocrinology: 247
• Year to date:
  • Site-wide: 82,570
• Since beginning of last month:
  • Site-wide: 136,845

Status Quo and Influencing Factors of Family Doctors Performance in Dongguan City

• Downloaded 185 times
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  • Site-wide: 190,941
  • In health systems and quality improvement: 343
• Year to date:
  • Site-wide: 144,615
• Since beginning of last month:
  • Site-wide: 157,464

Unifying genetic association tests via regression: Prospective and retrospective, parametric and non-parametric, and genotype- and allele-based tests

• Downloaded 181 times
• Download rankings, all-time:
  • Site-wide: 191,852
  • In genomics: 9,037
• Year to date:
  • Site-wide: 183,768
• Since beginning of last month:
  • Site-wide: 168,128

Manipulating Oxalate Decarboxylase Provides the Basis of Antilithic Therapy by Acting on the Gut Microbiota

• Downloaded 97 times
• Download rankings, all-time:
  • Site-wide: 208,083
  • In cell biology: 9,509
• Year to date:
  • Site-wide: 101,579
• Since beginning of last month:
  • Site-wide: 108,477

Stress-associated purinergic receptors code for fatal suicidality in the hippocampal-hypothalamic-prefrontal circuit

• Downloaded 85 times
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  • Site-wide: 210,187
  • In neuroscience: 30,448
• Year to date:
  • Site-wide: 39,528
• Since beginning of last month:
  • Site-wide: 16,929

Ocular findings, surgery details and outcomes in proliferative diabetic retinopathy patients with chronic kidney disease

• Downloaded 73 times
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  • Site-wide: 212,545
  • In ophthalmology: 261
• Year to date:
  • Site-wide: 187,711
• Since beginning of last month:
  • Site-wide: 106,504

The circadian clock gene bmal1 is necessary for co-ordinated circatidal rhythms in the marine isopod Eurydice pulchra (Leach).

• Downloaded 55 times
• Download rankings, all-time:
  • Site-wide: 215,265
  • In genetics: None
• Year to date:
  • Site-wide: 13,695
• Since beginning of last month:
  • Site-wide: 11,163