Author: Lin Zhang

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Preprints

Safety of hydroxychloroquine, alone and in combination with azithromycin, in light of rapid wide-spread use for COVID-19: a multinational, network cohort and self-controlled case series study

• Downloaded 34,629 times
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  • Site-wide: 176
  • In rheumatology: 1
• Year to date:
  • Site-wide: 1,078
• Since beginning of last month:
  • Site-wide: 1,560

Retrospective Analysis of Clinical Features in 101 Death Cases with COVID-19

• Downloaded 5,254 times
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  • Site-wide: 1,861
  • In intensive care and critical care medicine: 12
• Year to date:
  • Site-wide: 17,881
• Since beginning of last month:
  • Site-wide: 18,161

An international characterisation of patients hospitalised with COVID-19 and a comparison with those previously hospitalised with influenza

• Downloaded 5,112 times
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  • Site-wide: 1,922
  • In infectious diseases: 446
• Year to date:
  • Site-wide: 3,254
• Since beginning of last month:
  • Site-wide: 6,581

Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network

• Downloaded 2,490 times
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  • Site-wide: 5,424
  • In health informatics: 31
• Year to date:
  • Site-wide: 6,465
• Since beginning of last month:
  • Site-wide: 6,312

Integrated Proteogenomic Deep Sequencing and Analytics Accurately Identify Non-Canonical Peptides in Tumor Immunopeptidomes

• Downloaded 1,860 times
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  • Site-wide: 8,343
  • In cancer biology: 141
• Year to date:
  • Site-wide: 37,326
• Since beginning of last month:
  • Site-wide: 28,785

Screening for functional circular RNAs using the CRISPR-Cas13 system

• Downloaded 1,442 times
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  • Site-wide: 12,120
  • In molecular biology: 334
• Year to date:
  • Site-wide: 16,004
• Since beginning of last month:
  • Site-wide: 21,938

Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study

• Downloaded 1,408 times
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  • Site-wide: 12,588
  • In cardiovascular medicine: 16
• Year to date:
  • Site-wide: 21,841
• Since beginning of last month:
  • Site-wide: 20,395

Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study

• Downloaded 1,360 times
• Download rankings, all-time:
  • Site-wide: 13,295
  • In epidemiology: 886
• Year to date:
  • Site-wide: 5,907
• Since beginning of last month:
  • Site-wide: 5,981

A case of SARS-CoV-2 carrier for 32 days with several times false negative nucleic acid tests

• Downloaded 1,154 times
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  • Site-wide: 17,052
  • In infectious diseases: 1,565
• Year to date:
  • Site-wide: 70,109
• Since beginning of last month:
  • Site-wide: 45,240

Risk of depression, suicidal ideation, suicide and psychosis with hydroxychloroquine treatment for rheumatoid arthritis: a multi-national network cohort study

• Downloaded 959 times
• Download rankings, all-time:
  • Site-wide: 22,274
  • In epidemiology: 1,274
• Year to date:
  • Site-wide: 9,089
• Since beginning of last month:
  • Site-wide: 8,371

Characteristics, outcomes, and mortality amongst 133,589 patients with prevalent autoimmune diseases diagnosed with, and 48,418 hospitalised for COVID-19: a multinational distributed network cohort analysis

• Downloaded 857 times
• Download rankings, all-time:
  • Site-wide: 26,209
  • In epidemiology: 1,431
• Year to date:
  • Site-wide: 4,360
• Since beginning of last month:
  • Site-wide: 7,966

Heterogeneity and temporal variation in the management of COVID-19: a multinational drug utilization study including 71,921 hospitalized patients from China, South Korea, Spain, and the United States of America

• Downloaded 851 times
• Download rankings, all-time:
  • Site-wide: 26,497
  • In epidemiology: 1,442
• Year to date:
  • Site-wide: 14,101
• Since beginning of last month:
  • Site-wide: 18,634

Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: A multicenter cohort study

• Downloaded 611 times
• Download rankings, all-time:
  • Site-wide: 41,416
  • In infectious diseases: 2,439
• Year to date:
  • Site-wide: 72,650
• Since beginning of last month:
  • Site-wide: 44,028

simATAC: A single-cell ATAC-seq simulation framework

• Downloaded 607 times
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  • Site-wide: 41,756
  • In bioinformatics: 4,508
• Year to date:
  • Site-wide: 13,739
• Since beginning of last month:
  • Site-wide: 26,582

CytoGPS: A Web-Enabled Karyotype Analysis Tool for Cytogenetics

• Downloaded 577 times
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  • Site-wide: 44,467
  • In bioinformatics: 4,718
• Year to date:
  • Site-wide: 43,925
• Since beginning of last month:
  • Site-wide: 39,150

Can we trust the prediction model? Demonstrating the importance of external validation by investigating the COVID-19 Vulnerability (C-19) Index across an international network of observational healthcare datasets

• Downloaded 575 times
• Download rankings, all-time:
  • Site-wide: 44,620
  • In health informatics: 158
• Year to date:
  • Site-wide: 46,921
• Since beginning of last month:
  • Site-wide: 28,457

A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells

• Downloaded 538 times
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  • Site-wide: 48,420
  • In synthetic biology: 592
• Year to date:
  • Site-wide: 13,329
• Since beginning of last month:
  • Site-wide: 20,076

Genomic signatures of somatic hybrid vigor due to heterokaryosis in the oomycete pathogen, Bremia lactucae.

• Downloaded 533 times
• Download rankings, all-time:
  • Site-wide: 48,987
  • In genomics: 3,870
• Year to date:
  • Site-wide: 108,223
• Since beginning of last month:
  • Site-wide: 113,903

Characteristics and outcomes of 627 044 COVID-19 patients with and without obesity in the United States, Spain, and the United Kingdom

• Downloaded 532 times
• Download rankings, all-time:
  • Site-wide: 49,049
  • In epidemiology: 2,218
• Year to date:
  • Site-wide: 30,159
• Since beginning of last month:
  • Site-wide: 30,361

Systematic evaluation of parameters for genome-scale metabolic models of cultured mammalian cells

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 54,420
  • In systems biology: 1,299
• Year to date:
  • Site-wide: 26,771
• Since beginning of last month:
  • Site-wide: 38,202

Circulating Clonally Expanded T Cells Reflect Functions of Tumor Infiltrating T Cells

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 54,622
  • In immunology: 1,523
• Year to date:
  • Site-wide: 12,020
• Since beginning of last month:
  • Site-wide: 6,948

Baseline phenotype and 30-day outcomes of people tested for COVID-19: an international network cohort including >3.32 million people tested with real-time PCR and >219,000 tested positive for SARS-CoV-2 in South Korea, Spain and the United States

• Downloaded 459 times
• Download rankings, all-time:
  • Site-wide: 58,120
  • In infectious diseases: 2,851
• Year to date:
  • Site-wide: 20,759
• Since beginning of last month:
  • Site-wide: 24,110

Epidemiological and Clinical Characteristics of COVID-19 Patients with Cancers: A Systematic Review and Meta-Analysis of Global Data

• Downloaded 411 times
• Download rankings, all-time:
  • Site-wide: 65,100
  • In oncology: 82
• Year to date:
  • Site-wide: 47,876
• Since beginning of last month:
  • Site-wide: 42,909

Risk assessment and prediction of severe or critical illness of COVID-19 in the elderly

• Downloaded 408 times
• Download rankings, all-time:
  • Site-wide: 65,637
  • In public and global health: 794
• Year to date:
  • Site-wide: 106,292
• Since beginning of last month:
  • Site-wide: 83,386

Clinical characteristics, symptoms, management and health outcomes in 8,598 pregnant women diagnosed with COVID-19 compared to 27,510 with seasonal influenza in France, Spain and the US: a network cohort analysis

• Downloaded 394 times
• Download rankings, all-time:
  • Site-wide: 67,724
  • In infectious diseases: 3,054
• Year to date:
  • Site-wide: 25,539
• Since beginning of last month:
  • Site-wide: 18,903

Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 240,392 patients hospitalized with COVID-19 in the United States

• Downloaded 392 times
• Download rankings, all-time:
  • Site-wide: 68,186
  • In infectious diseases: 3,066
• Year to date:
  • Site-wide: 12,605
• Since beginning of last month:
  • Site-wide: 9,459

The Tung Tree (Vernicia Fordii) Genome Provides A Resource for Understanding Genome Evolution and Oil Improvement

• Downloaded 388 times
• Download rankings, all-time:
  • Site-wide: 68,709
  • In bioinformatics: 6,619
• Year to date:
  • Site-wide: 87,397
• Since beginning of last month:
  • Site-wide: 100,865

On a Unifying ‘Reverse’ Regression for Robust Association Studies and Allele Frequency Estimation with Related Individuals

• Downloaded 353 times
• Download rankings, all-time:
  • Site-wide: 74,872
  • In genetics: 3,426
• Year to date:
  • Site-wide: 82,171
• Since beginning of last month:
  • Site-wide: 99,172

Effects of sugars and lipids on the growth and development of Caenorhabditis elegans

• Downloaded 328 times
• Download rankings, all-time:
  • Site-wide: 79,607
  • In genetics: 3,620
• Year to date:
  • Site-wide: 82,743
• Since beginning of last month:
  • Site-wide: 87,549

Outcomes of ureteroscopy and internal ureteral stent for pregnancy with urolithiasis: a systematic review and meta-analysis

• Downloaded 327 times
• Download rankings, all-time:
  • Site-wide: 79,754
  • In urology: 27
• Year to date:
  • Site-wide: 15,187
• Since beginning of last month:
  • Site-wide: 15,742

Dissecting molecular regulatory mechanisms underlying noncoding susceptibility SNPs associated with 19 autoimmune diseases using multi-omics integrative analysis

• Downloaded 316 times
• Download rankings, all-time:
  • Site-wide: 81,922
  • In immunology: 2,293
• Year to date:
  • Site-wide: 97,981
• Since beginning of last month:
  • Site-wide: 133,139

AFLAP: Assembly-Free Linkage Analysis Pipeline using k-mers from whole genome sequencing data

• Downloaded 313 times
• Download rankings, all-time:
  • Site-wide: 82,519
  • In genetics: 3,741
• Year to date:
  • Site-wide: 29,911
• Since beginning of last month:
  • Site-wide: 44,352

Conserving unprotected important coastal habitats in the Yellow Sea: shorebird occurrence, distribution and food resources at Lianyungang

• Downloaded 295 times
• Download rankings, all-time:
  • Site-wide: 86,332
  • In ecology: 2,671
• Year to date:
  • Site-wide: 125,407
• Since beginning of last month:
  • Site-wide: 120,806

A Generalized Robust Allele-based Genetic Association Test

• Downloaded 276 times
• Download rankings, all-time:
  • Site-wide: 90,466
  • In genetics: 4,071
• Year to date:
  • Site-wide: 40,997
• Since beginning of last month:
  • Site-wide: 18,582

Nonlinear Dispersive Cell Model for Microdosimetry of Nanosecond Pulsed Electric Fields

• Downloaded 275 times
• Download rankings, all-time:
  • Site-wide: 90,634
  • In bioengineering: 1,712
• Year to date:
  • Site-wide: 125,210
• Since beginning of last month:
  • Site-wide: 111,626

Sub physiological temperature induces pervasive alternative splicing in Chinese hamster ovary cells

• Downloaded 268 times
• Download rankings, all-time:
  • Site-wide: 92,107
  • In cell biology: 4,263
• Year to date:
  • Site-wide: 70,836
• Since beginning of last month:
  • Site-wide: 59,485

Characteristics and outcomes of 118,155 COVID-19 individuals with a history of cancer in the United States and Spain

• Downloaded 255 times
• Download rankings, all-time:
  • Site-wide: 94,977
  • In epidemiology: 3,895
• Year to date:
  • Site-wide: 7,917
• Since beginning of last month:
  • Site-wide: 24,771

The rice G protein γ subunit qPE9-1 positively regulates grain-filling process by interacting with abscisic acid and auxin

• Downloaded 251 times
• Download rankings, all-time:
  • Site-wide: 95,921
  • In plant biology: 2,581
• Year to date:
  • Site-wide: 117,613
• Since beginning of last month:
  • Site-wide: 114,498

A genome-scale metabolic network model and machine learning predict amino acid concentrations in Chinese Hamster Ovary cell cultures

• Downloaded 247 times
• Download rankings, all-time:
  • Site-wide: 96,780
  • In systems biology: 2,259
• Year to date:
  • Site-wide: 34,006
• Since beginning of last month:
  • Site-wide: 39,931

Toxicities of PD-1/PD-L1 Inhibitors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Downloaded 233 times
• Download rankings, all-time:
  • Site-wide: 99,762
  • In oncology: 196
• Year to date:
  • Site-wide: 42,836
• Since beginning of last month:
  • Site-wide: 35,639

Expanding the Chinese hamster ovary cell long non-coding RNA transcriptome using RNASeq

• Downloaded 232 times
• Download rankings, all-time:
  • Site-wide: 100,059
  • In cell biology: 4,650
• Year to date:
  • Site-wide: 81,147
• Since beginning of last month:
  • Site-wide: 67,992

Microbial Species Abundance Distributions Guide Human Population Size Estimation from Sewage Metagenomes

• Downloaded 229 times
• Download rankings, all-time:
  • Site-wide: 100,600
  • In bioinformatics: 8,621
• Year to date:
  • Site-wide: 30,163
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  • Site-wide: 55,992

Association Between Blood Circulating Vitamin D and Colorectal Cancer Risk in Asian Countries: A Systematic Review and Dose-Response Meta-analysis

• Downloaded 211 times
• Download rankings, all-time:
  • Site-wide: 104,787
  • In oncology: 228
• Year to date:
  • Site-wide: 89,985
• Since beginning of last month:
  • Site-wide: 70,412

mTORC2 mediate FLCN-induced HIF2α nuclear import and proliferation of clear cell renal cell carcinoma

• Downloaded 200 times
• Download rankings, all-time:
  • Site-wide: 107,122
  • In cell biology: 4,975
• Year to date:
  • Site-wide: 128,309
• Since beginning of last month:
  • Site-wide: 124,319

Quantitatively Monitoring in situ Mitochondrial Thermal Dynamics by Upconversion Nanoparticles

• Downloaded 190 times
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  • Site-wide: 109,314
  • In cell biology: 5,069
• Year to date:
  • Site-wide: 41,657
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  • Site-wide: 48,673

Targeted over-expression of PPARγ in pig skeletal muscle improves oxidative fiber formation and intramuscular fat deposition

• Downloaded 167 times
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  • Site-wide: 114,340
  • In genetics: 4,944
• Year to date:
  • Site-wide: 65,109
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  • Site-wide: 76,694

Characteristics and influence of type 2 diabetes in cirrhosis ascites with spontaneous bacterial peritonitis

• Downloaded 142 times
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  • Site-wide: 119,415
  • In endocrinology: 103
• Year to date:
  • Site-wide: 83,201
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  • Site-wide: 78,464

Dopamine receptor DOP-1 engages a sleep pathway to modulate swimming in C. elegans

• Downloaded 118 times
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  • Site-wide: 124,215
  • In genetics: 5,247
• Year to date:
  • Site-wide: 21,675
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  • Site-wide: 38,484

Leveraging Hardy-Weinberg disequilibrium for association testing in case-control studies

• Downloaded 97 times
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  • Site-wide: 127,971
  • In genetics: 5,343
• Year to date:
  • Site-wide: 114,659
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  • Site-wide: 83,106

EZH2 Engages TGFβ Signaling to Promote Breast Cancer Bone Metastasis via Integrin β1-FAK Activation

• Downloaded 95 times
• Download rankings, all-time:
  • Site-wide: 128,219
  • In cancer biology: 4,013
• Year to date:
  • Site-wide: 27,597
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  • Site-wide: 65,305

Correlation between serum 25(OH) vitamin D level and sleep quality in elderly patients with type 2 diabetes

• Downloaded 89 times
• Download rankings, all-time:
  • Site-wide: 129,178
  • In endocrinology: 147
• Year to date:
  • Site-wide: 101,629
• Since beginning of last month:
  • Site-wide: 78,311