Author: Wei Wang

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Preprints

Association of Age-Related Macular Degeneration With Mortality: A Propensity Score-Matched Analysis

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Association of Retinal Age Gap with Arterial Stiffness and Incident Cardiovascular Disease

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Comorbidity and its impact on 1,590 patients with COVID-19 in China: A Nationwide Analysis

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  • Site-wide: 380
  • In respiratory medicine: 4
• Year to date:
  • Site-wide: 2,932
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  • Site-wide: 7,201

COVID-19 in Wuhan: Immediate Psychological Impact on 5062 Health Workers

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  • Site-wide: 1,044
  • In psychiatry and clinical psychology: 6
• Year to date:
  • Site-wide: 2,652
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  • Site-wide: 2,985

Age profile of susceptibility, mixing, and social distancing shape the dynamics of the novel coronavirus disease 2019 outbreak in China

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  • Site-wide: 1,060
  • In epidemiology: 151
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  • Site-wide: 14,437
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Modified TCA/acetone precipitation of plant proteins for proteomic analysis

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  • Site-wide: 1,305
  • In biochemistry: 14
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  • Site-wide: 2,272
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  • Site-wide: 6,341

Environmental contamination of the SARS-CoV-2 in healthcare premises: An urgent call for protection for healthcare workers

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  • Site-wide: 1,484
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Global profiling of SARS-CoV-2 specific IgG/ IgM responses of convalescents using a proteome microarray

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  • Site-wide: 1,941
  • In infectious diseases: 549
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  • Site-wide: 12,949

Is Oculudentavis a bird or even archosaur?

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  • Site-wide: 2,601
  • In evolutionary biology: 36
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Systematic mapping of chromatin state landscapes during mouse development

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  • Site-wide: 2,910
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CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos

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  • Site-wide: 3,064
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Detection of 2019 novel coronavirus in semen and testicular biopsy specimen of COVID-19 patients

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  • Site-wide: 3,079
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  • Site-wide: 27,206

Evolving epidemiology of novel coronavirus diseases 2019 and possible interruption of local transmission outside Hubei Province in China: a descriptive and modeling study

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  • Site-wide: 3,837
  • In infectious diseases: 846
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  • Site-wide: 25,025

Infectivity, susceptibility, and risk factors associated with SARS-CoV-2 transmission under intensive contact tracing in Hunan, China

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  • Site-wide: 5,360
  • In infectious diseases: 1,050
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  • Site-wide: 19,666

The Use of Adjuvant Therapy in Preventing Progression to Severe Pneumonia in Patients with Coronavirus Disease 2019: A Multicenter Data Analysis

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  • Site-wide: 5,592
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A single cell transcriptional roadmap for cardiopharyngeal fate diversification

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  • Site-wide: 6,132
  • In developmental biology: 65
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Early Prediction of Disease Progression in 2019 Novel Coronavirus Pneumonia Patients Outside Wuhan with CT and Clinical Characteristics

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In-Vivo Toxicity Studies and In-Vitro Inactivation of SARS-CoV-2 by Povidone-iodine In-situ Gel Forming Formulations

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  • Site-wide: 7,743
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Assessment of single cell RNA-seq normalization methods

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  • Site-wide: 8,465
  • In bioinformatics: 915
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  • Site-wide: 81,367
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  • Site-wide: 127,627

Case fatality risk of novel coronavirus diseases 2019 in China

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  • Site-wide: 9,119
  • In infectious diseases: 1,455
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  • Site-wide: 22,501
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  • Site-wide: 79,527

GSKB: A gene set database for pathway analysis in mouse

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  • Site-wide: 9,528
  • In bioinformatics: 1,033
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  • Site-wide: 10,480

SHP2 Inhibition Abrogates Adaptive Resistance to KRASG12C-Inhibition and Remodels the Tumor Microenvironment of KRAS-Mutant Tumors

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  • Site-wide: 10,386
  • In cancer biology: 179
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  • Site-wide: 13,694

Persistent SARS-CoV-2 presence is companied with defects in adaptive immune system in non-severe COVID-19 patients

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  • Site-wide: 11,457
  • In infectious diseases: 1,643
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  • Site-wide: 76,286

Establishment In Culture Of Expanded Potential Stem Cells

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  • Site-wide: 11,611
  • In developmental biology: 148
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  • Site-wide: 47,793
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  • Site-wide: 103,536

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1

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  • Site-wide: 12,623
  • In genomics: 1,227
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  • Site-wide: 79,845
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  • Site-wide: 101,854

The Effectiveness of China’s National Forest Protection Program and National-level Nature Reserves, 2000 to 2010

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  • Site-wide: 14,647
  • In ecology: 191
• Year to date:
  • Site-wide: 108,963
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  • Site-wide: 96,195

Role of short-chain fatty acids in the gut-brain axis in schizophrenia: contribution to immune activation and pathophysiology in humans and mice

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  • Site-wide: 15,209
  • In neuroscience: 1,663
• Year to date:
  • Site-wide: 15,575
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  • Site-wide: 19,734

Recurrence of cancer cell states across diverse tumors and their interactions with the microenvironment

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  • Site-wide: 15,633
  • In cancer biology: 326
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  • Site-wide: 401
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  • Site-wide: 233

Identification of DNA motifs that regulate DNA methylation

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  • Site-wide: 16,427
  • In bioinformatics: 1,820
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  • Site-wide: 39,559
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  • Site-wide: 68,266

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

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  • Site-wide: 17,544
  • In cell biology: 527
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  • Site-wide: 17,339
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  • Site-wide: 26,858

Single-cell transcriptome profiling of the Ciona larval brain

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  • Site-wide: 17,873
  • In developmental biology: 270
• Year to date:
  • Site-wide: 39,065
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  • Site-wide: 122,805

Cardiac Structural and Functional Characteristics in Patients with Coronavirus Disease 2019: A Serial Echocardiographic Study

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  • Site-wide: 22,808
  • In cardiovascular medicine: 34
• Year to date:
  • Site-wide: 19,162
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  • Site-wide: 26,866

Assessing the measurement transfer function of single-cell RNA sequencing

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  • Site-wide: 23,577
  • In genomics: 2,132
• Year to date:
  • Site-wide: 126,644
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  • Site-wide: 148,984

Association of Personal Protective Equipment Use with Successful Protection Against COVID-19 Infection Among Health Care Workers

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  • Site-wide: 23,976
  • In epidemiology: 1,463
• Year to date:
  • Site-wide: 15,738
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  • Site-wide: 48,596

TahcoRoll: An Efficient Approach for Signature Profiling in Genomic Data through Variable-Length k-mers

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  • Site-wide: 24,042
  • In bioinformatics: 2,664
• Year to date:
  • Site-wide: 111,469
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  • Site-wide: 94,800

Finding de novo methylated DNA motifs

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  • Site-wide: 24,178
  • In bioinformatics: 2,677
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  • Site-wide: 116,494
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  • Site-wide: 152,517

Hybrid origins and the earliest stages of diploidization in the highly successful recent polyploid Capsella bursa-pastoris

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  • Site-wide: 24,385
  • In evolutionary biology: 918
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  • Site-wide: 163,476

Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivo

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  • Site-wide: 24,398
  • In microbiology: 1,406
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Loss of SATB1 Induces a p21 Dependent Cellular Senescence Phenotype in Dopaminergic Neurons

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  • Site-wide: 27,671
  • In neuroscience: 3,425
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  • Site-wide: 68,740

Identification of gut microbiome markers for schizophrenia delineates a potential role of Streptococcus

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  • Site-wide: 27,985
  • In microbiology: 1,615
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  • Site-wide: 77,389

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

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  • Site-wide: 28,446
  • In genetic and genomic medicine: 145
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  • Site-wide: 23,843

The RNA-binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria

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  • Site-wide: 28,713
  • In genetics: 1,235
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  • Site-wide: 82,221

Molecular Crowding Tunes Material States of Ribonucleoprotein Condensates

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  • Site-wide: 29,221
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Association of 25 hydroxyvitamin D concentration with risk of COVID-19: a Mendelian randomization study

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  • Site-wide: 30,443
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Large-scale trans-ethnic replication and discovery of genetic associations for rare diseases with self-reported medical data

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  • Site-wide: 31,702
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  • Site-wide: 13,726

Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath

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  • Site-wide: 32,745
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  • Site-wide: 45,768

Co-expression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

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  • Site-wide: 33,249
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A nuclear hormone receptor and lipid metabolism axis are required for the maintenance and regeneration of reproductive organs

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  • Site-wide: 33,394
  • In developmental biology: 650
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Linear epitopes of SARS-CoV-2 spike protein elicit neutralizing antibodies in COVID-19 patients

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  • Site-wide: 34,630
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Global, regional, and national estimates of target population sizes for COVID-19 vaccination

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  • Site-wide: 36,380
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Full-genome evolutionary histories of selfing, splitting and selection in Caenorhabditis

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Computational Study of Ions and Water Permeation and Transportation Mechanisms of the SARS-CoV-2 Pentameric E Protein Channel

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  • Site-wide: 37,435
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  • Site-wide: 38,989

An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time

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  • Site-wide: 38,582
  • In developmental biology: 785
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Contemporary circulating enterovirus D68 strains show differential viral entry and replication in human neuronal cells

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  • Site-wide: 38,635
  • In microbiology: 2,297
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Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in the murine cardiopharyngeal mesoderm

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  • Site-wide: 39,617
  • In developmental biology: 827
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Molecular evolution across developmental time reveals rapid divergence in early embryogenesis

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  • Site-wide: 40,921
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  • Site-wide: 100,575

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

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  • Site-wide: 41,284
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  • Site-wide: 59,902

Paralogues of the PXY and ER receptor kinases enforce radial patterning in plant vascular tissue.

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  • Site-wide: 42,511
  • In plant biology: 848
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Motto: Representing motifs in consensus sequences with minimum information loss

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  • Site-wide: 44,425
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MiniScrub: de novo long read scrubbing using approximate alignment and deep learning

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  • Site-wide: 44,959
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Systematic identification of cooperation between DNA binding proteins in 3D space

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  • Site-wide: 151,232

Systems-level identification of transcription factors critical for mouse embryonic development

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Lasagna: Multifaceted Protein-Protein Interaction Prediction Based on Siamese Residual RCNN

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  • Site-wide: 46,884
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Prophase removal of chromosome-associated RNAs facilitates anaphase chromosome segregation

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JEDI: Circular RNA Prediction based on Junction Encoders and Deep Interaction among Splice Sites

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Interplay Between Short-range Attraction and Long-range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein-RNA Complexes

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Global variability of the human IgG glycome

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Association between Alzheimer's disease and COVID-19: A bidirectional Mendelian randomization

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Genome structure predicts modular transcriptome responses to genetic and environmental conditions

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Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

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  • Site-wide: 152,655
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  • Site-wide: 117,998

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

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Nationwide population genetic screening improves outcomes of newborn screening for hearing loss in China

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Genome-wide association analysis and replication in 810,625 individuals identifies novel therapeutic targets for varicose veins

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Mechanisms of integrin αVβ5 clustering in flat clathrin lattices

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Neurogenin regulates effectors of migratory neuron cell behaviors in Ciona

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Xist Intron 1 Repression by TALE Transcriptional Factor Improves Somatic Cell Reprogamming in Mice

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  • Site-wide: 63,340
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  • Site-wide: 123,302

Identification of 67 pleiotropic genes for seven autoimmune diseases using multivariate statistical analysis

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  • Site-wide: 64,935
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  • Site-wide: 150,122

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

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Cell Cycle, Energy Metabolism and DNA Repair Pathways in Cancer Cells are Suppressed by Compound Kushen Injection.

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Fecal microbiota as a non-invasive biomarker to predict the tissue iron accumulation in intestine epithelial cells and liver

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Experimental Stroke Induces Chronic Gut Dysbiosis and Neuroinflammation in Male Mice

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Non-parametric and semi-parametric support estimation using SEquential RESampling random walks on biomolecular sequences

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Build a Better Bootstrap and the RAWR Shall Beat a Random Path to Your Door: Phylogenetic Support Estimation Revisited

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Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

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  • In evolutionary biology: 3,619
• Year to date:
  • Site-wide: 42,820
• Since beginning of last month:
  • Site-wide: 89,010

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

• Downloaded 514 times
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  • Site-wide: 73,715
  • In cancer biology: 2,141
• Year to date:
  • Site-wide: 154,133
• Since beginning of last month:
  • Site-wide: 66,274

Bacterial Glycogen as a Durable Energy Reserve Contributing to Persistence: An Updated Bibliography and Mathematical Model

• Downloaded 506 times
• Download rankings, all-time:
  • Site-wide: 74,965
  • In microbiology: 4,885
• Year to date:
  • Site-wide: 85,842
• Since beginning of last month:
  • Site-wide: 128,712

Cell cycle-gated feedback control mediates desensitization to interferon stimulation

• Downloaded 503 times
• Download rankings, all-time:
  • Site-wide: 75,620
  • In systems biology: 1,653
• Year to date:
  • Site-wide: 45,801
• Since beginning of last month:
  • Site-wide: 138,319

Targeted mutations on 3D hub loci alter spatial interaction environment

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 78,436
  • In biophysics: 2,816
• Year to date:
  • Site-wide: 134,321
• Since beginning of last month:
  • Site-wide: 71,808

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

• Downloaded 487 times
• Download rankings, all-time:
  • Site-wide: 78,454
  • In pharmacology and toxicology: 509
• Year to date:
  • Site-wide: 138,949
• Since beginning of last month:
  • Site-wide: 97,862

Screening of FDA-approved Drugs and Identification of Novel Lassa Virus Entry Inhibitors

• Downloaded 486 times
• Download rankings, all-time:
  • Site-wide: 78,464
  • In microbiology: 5,149
• Year to date:
  • Site-wide: 112,863
• Since beginning of last month:
  • Site-wide: 94,603

Systematic profiling of SARS-CoV-2 specific IgG epitopes at single amino acid resolution

• Downloaded 485 times
• Download rankings, all-time:
  • Site-wide: 78,753
  • In epidemiology: 3,497
• Year to date:
  • Site-wide: 101,340
• Since beginning of last month:
  • Site-wide: 56,776

Mutation effect estimation on protein-protein interactions using deep contextualized representation learning

• Downloaded 478 times
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  • Site-wide: 80,084
  • In bioinformatics: 7,264
• Year to date:
  • Site-wide: 105,091
• Since beginning of last month:
  • Site-wide: 164,650

Bio-JOIE: Joint Representation Learning of Biological Knowledge Bases

• Downloaded 475 times
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  • Site-wide: 80,512
  • In bioinformatics: 7,307
• Year to date:
  • Site-wide: 148,801
• Since beginning of last month:
  • Site-wide: 112,190

Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome

• Downloaded 460 times
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  • Site-wide: 83,524
  • In neuroscience: 12,246
• Year to date:
  • Site-wide: 88,212
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  • Site-wide: 120,311

Surfaceome CRISPR Screen Identifies OLFML3 as a Rhinovirus-inducible IFN Antagonist

• Downloaded 446 times
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  • Site-wide: 86,332
  • In molecular biology: 2,529
• Year to date:
  • Site-wide: 60,776
• Since beginning of last month:
  • Site-wide: 66,668

Uncovering Medical Insights from Vast Amounts of Biomedical Data in Clinical Case Reports

• Downloaded 444 times
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  • Site-wide: 86,684
  • In bioinformatics: 7,736
• Year to date:
  • Site-wide: 115,333
• Since beginning of last month:
  • Site-wide: 152,076

A multiethnic GWAS meta-analysis of 585,243 individuals identifies new risk loci associated with cataract and reveals sex-specific effects

• Downloaded 442 times
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  • Site-wide: 87,173
  • In genetic and genomic medicine: 449
• Year to date:
  • Site-wide: 35,779
• Since beginning of last month:
  • Site-wide: 65,139

Latent defense response to non-pathogenic microbial factors impairs plant-rhizobacteria mutualism

• Downloaded 433 times
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  • Site-wide: 89,008
  • In plant biology: 2,318
• Year to date:
  • Site-wide: 107,158
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  • Site-wide: 74,815

Dual functions of Discoidin domain receptor coordinate cell-matrix adhesion and collective polarity in migratory cardiopharyngeal progenitors

• Downloaded 429 times
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  • Site-wide: 89,739
  • In developmental biology: 2,364
• Year to date:
  • Site-wide: 131,873
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  • Site-wide: 143,637

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

• Downloaded 422 times
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  • Site-wide: 91,276
  • In microbiology: 6,104
• Year to date:
  • Site-wide: 147,479
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  • Site-wide: 77,778

Recovery of Consciousness and Cognition after General Anesthesia in Humans

• Downloaded 419 times
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  • Site-wide: 91,846
  • In neuroscience: 13,582
• Year to date:
  • Site-wide: 103,886
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  • Site-wide: 137,770

Genome-wide analysis identifies cis-acting elements regulating mRNA polyadenylation and translation during vertebrate oocyte maturation

• Downloaded 414 times
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  • Site-wide: 92,767
  • In genomics: 5,786
• Year to date:
  • Site-wide: 128,417
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  • Site-wide: 158,516

Contextual Regression: An Accurate and Conveniently Interpretable Nonlinear Model for Mining Discovery from Scientific Data

• Downloaded 400 times
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  • Site-wide: 96,047
  • In bioinformatics: 8,330
• Year to date:
  • Site-wide: 132,909
• Since beginning of last month:
  • Site-wide: 152,320

Screening of Botanical Drugs against SARS-CoV-2 Entry

• Downloaded 396 times
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  • Site-wide: 96,865
  • In microbiology: 6,584
• Year to date:
  • Site-wide: 91,252
• Since beginning of last month:
  • Site-wide: 58,637

DTI-CDF: a CDF model towards the prediction of DTIs based on hybrid features

• Downloaded 394 times
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  • Site-wide: 97,320
  • In bioinformatics: 8,412
• Year to date:
  • Site-wide: 86,876
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  • Site-wide: 156,371

Association between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes mellitus

• Downloaded 387 times
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  • Site-wide: 98,850
  • In pathology: 509
• Year to date:
  • Site-wide: 22,567
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  • Site-wide: 66,506

Human Cytomegalovirus Immediate-Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus

• Downloaded 387 times
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  • Site-wide: 98,986
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  • Site-wide: 129,958
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  • Site-wide: 123,589

Role of Water-bridged Interactions in Metal Ion Coupled Protein Allostery

• Downloaded 386 times
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  • Site-wide: 99,072
  • In biochemistry: 2,876
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  • Site-wide: None
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  • Site-wide: 154,888

Structural basis for transfer RNA mimicry by a bacterial Y RNA

• Downloaded 383 times
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  • Site-wide: 99,791
  • In biochemistry: 2,897
• Year to date:
  • Site-wide: 143,604
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  • Site-wide: 146,909

NEIL1 and NEIL2 DNA glycosylases regulate anxiety and learning in a cooperative manner

• Downloaded 378 times
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  • Site-wide: 101,203
  • In molecular biology: 2,991
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  • Site-wide: 120,168
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  • Site-wide: 50,211

Efficacy and Acceptability Comparisons of Cognitive Behavior Therapy, Drugs, and Their Combination for Panic Disorder in Adults: a Network Meta-analysis

• Downloaded 373 times
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  • Site-wide: 102,208
  • In psychiatry and clinical psychology: 457
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  • Site-wide: 74,508
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  • Site-wide: 61,087

Comparative Transcriptomes Analysis of Taenia pisiformis at Different Development Stages

• Downloaded 370 times
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  • Site-wide: 103,032
  • In molecular biology: 3,049
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  • Site-wide: 138,178
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  • Site-wide: 124,599

Causal associations between COVID-19 and Atrial Fibrillation: A bidirectional Mendelian randomization study

• Downloaded 366 times
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  • Site-wide: 103,930
  • In genetic and genomic medicine: 586
• Year to date:
  • Site-wide: 152,162
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  • Site-wide: 88,638

An Analysis of Outbreak Dynamics and Intervention Effects for COVID-19 Transmission in Europe

• Downloaded 360 times
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  • Site-wide: 105,557
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  • Site-wide: 100,312
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  • Site-wide: 113,601

Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

• Downloaded 358 times
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  • Site-wide: 105,798
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  • Site-wide: 58,016
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  • Site-wide: 56,613

Testosterone Changes in Female Pandas in Estrus

• Downloaded 343 times
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  • Site-wide: 109,793
  • In zoology: 420
• Year to date:
  • Site-wide: 71,571
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  • Site-wide: 165,834

The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in Escherichia coli

• Downloaded 342 times
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  • Site-wide: 110,031
  • In molecular biology: 3,258
• Year to date:
  • Site-wide: 106,626
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  • Site-wide: 80,076

Sulforaphane modulates microRNA expression in colon cancer cells to implicate the regulation of oncogenes CDC25A, HMGA2 and MYC

• Downloaded 340 times
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  • Site-wide: 110,507
  • In cancer biology: 3,320
• Year to date:
  • Site-wide: 38,873
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  • Site-wide: 102,756

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

• Downloaded 339 times
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  • Site-wide: 110,706
  • In pharmacology and toxicology: 797
• Year to date:
  • Site-wide: 77,210
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  • Site-wide: 47,132

Chinese medicine (Q-14) in the Treatment of Patients with Coronavirus Disease 2019 (COVID-19): A Single-center, Open label, Randomised Controlled Trial

• Downloaded 337 times
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  • Site-wide: 111,221
  • In infectious diseases: 5,239
• Year to date:
  • Site-wide: 14,809
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  • Site-wide: 32,769

Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq

• Downloaded 331 times
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  • Site-wide: 112,941
  • In genomics: 6,487
• Year to date:
  • Site-wide: 100,875
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  • Site-wide: 137,637

Autophagy Decreases Alveolar Epithelial Cell Injury by Suppressing the NF-κB Signaling Pathway and Regulating the Release of Inflammatory Mediators

• Downloaded 310 times
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  • Site-wide: 118,225
  • In cell biology: 5,493
• Year to date:
  • Site-wide: 83,360
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  • Site-wide: 124,339

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

• Downloaded 307 times
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  • Site-wide: 119,086
  • In pharmacology and toxicology: 882
• Year to date:
  • Site-wide: 142,719
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  • Site-wide: 160,280

Impact of Retinopathy and Systemic Vascular Comorbidities on All-Cause Mortality

• Downloaded 298 times
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  • Site-wide: 121,479
  • In ophthalmology: 137
• Year to date:
  • Site-wide: 153,627
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  • Site-wide: 88,129

Androgen Promotes Differentiation of PLZF+ Spermatogonia pool via Indirect Regulatory Pattern

• Downloaded 297 times
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  • Site-wide: 121,865
  • In developmental biology: 3,284
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  • Site-wide: None
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  • Site-wide: 122,994

The Report on China-Spain Joint Clinical Testing for Rapid COVID-19 Risk Screening by Eye-region Manifestations

• Downloaded 295 times
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  • Site-wide: 122,284
  • In ophthalmology: 143
• Year to date:
  • Site-wide: 4,552
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  • Site-wide: 9,681

Thm2 interacts with paralog, Thm1, and sensitizes to Hedgehog signaling in postnatal skeletogenesis

• Downloaded 290 times
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  • Site-wide: 123,683
  • In developmental biology: 3,340
• Year to date:
  • Site-wide: 153,672
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  • Site-wide: 135,986

Loss of tissue non-specific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis

• Downloaded 287 times
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  • Site-wide: 124,469
  • In neuroscience: 18,645
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  • Site-wide: 129,225
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  • Site-wide: 148,659

Mechanical dysfunction induced by a hypertrophic cardiomyopathy mutation is the primary driver of cellular adaptation

• Downloaded 283 times
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  • Site-wide: 125,490
  • In biophysics: 4,815
• Year to date:
  • Site-wide: None
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  • Site-wide: 113,841

Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary protein trafficking, Hedgehog signaling and embryogenesis

• Downloaded 281 times
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  • Site-wide: 126,223
  • In genetics: 5,026
• Year to date:
  • Site-wide: 142,093
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  • Site-wide: 90,521

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming

• Downloaded 275 times
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  • Site-wide: 127,688
  • In neuroscience: 19,123
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  • Site-wide: None
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  • Site-wide: 158,190

Oncogenic Activation of AKT by MAPK6

• Downloaded 269 times
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  • Site-wide: 129,392
  • In cancer biology: 3,930
• Year to date:
  • Site-wide: 156,281
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  • Site-wide: 138,947

Increased p53 signaling impairs neural differentiation causing HUWE1-promoted intellectual disabilities

• Downloaded 268 times
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  • Site-wide: 129,799
  • In cell biology: 6,004
• Year to date:
  • Site-wide: 106,029
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  • Site-wide: 167,658

A universal approach for integrating super large-scale single-cell transcriptomes by exploring gene rankings

• Downloaded 249 times
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  • Site-wide: 134,956
  • In bioinformatics: 10,682
• Year to date:
  • Site-wide: 69,578
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  • Site-wide: 27,672

Prediction of LncRNA Encoded Small Peptides in Glioma and The Oligomer Channel Functional Analysis Using in Silico Approaches

• Downloaded 239 times
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  • Site-wide: 137,489
  • In biophysics: 5,277
• Year to date:
  • Site-wide: 105,581
• Since beginning of last month:
  • Site-wide: 115,376

Integrative analysis with expanded DNA methylation data reveals common key regulators and pathways in cancers

• Downloaded 232 times
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  • Site-wide: 139,519
  • In bioinformatics: 10,948
• Year to date:
  • Site-wide: 138,720
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  • Site-wide: 125,612

The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy

• Downloaded 210 times
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  • Site-wide: 145,207
  • In physiology: 1,585
• Year to date:
  • Site-wide: 153,430
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  • Site-wide: 135,785

Brassinosteroids Promote Parenchyma Cell and Secondary Xylem Development in Sugar Beet (Beta vulgaris L.) Root

• Downloaded 195 times
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  • Site-wide: 148,992
  • In plant biology: 4,152
• Year to date:
  • Site-wide: 105,609
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  • Site-wide: 164,060

RNAi screening reveals requirement for PDGFRβ in JEV infection.

• Downloaded 192 times
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  • Site-wide: 149,627
  • In microbiology: 11,110
• Year to date:
  • Site-wide: 155,113
• Since beginning of last month:
  • Site-wide: 87,988

Limbal Niche Cells in Three-Dimensional Matrigel Induced Dedifferentiation of Mature Corneal Epithelial Cells toward a Progenitor State

• Downloaded 179 times
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  • Site-wide: 152,481
  • In bioengineering: 3,138
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  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 142,465

IFT-A deficiency in juvenile mice impairs biliary development and exacerbates ADPKD liver disease

• Downloaded 175 times
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  • Site-wide: 153,527
  • In genetics: 5,891
• Year to date:
  • Site-wide: 102,073
• Since beginning of last month:
  • Site-wide: 139,771

T-cell Repertoire Characteristics of Asymptomatic and Re-detectable Positive COVID-19 Patients

• Downloaded 169 times
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  • Site-wide: 154,699
  • In immunology: 4,751
• Year to date:
  • Site-wide: 119,941
• Since beginning of last month:
  • Site-wide: 132,340

Stand-alone lipoylated H-protein of the glycine cleavage system enables glycine cleavage and the synthesis of glycine from one-carbon compounds in vitro

• Downloaded 167 times
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  • Site-wide: 155,142
  • In biochemistry: 4,766
• Year to date:
  • Site-wide: 120,350
• Since beginning of last month:
  • Site-wide: 89,578

Genome-wide identification of long non-coding RNAs in the gravid ectoparasite Varroa destructor

• Downloaded 162 times
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  • Site-wide: 156,159
  • In genomics: 7,832
• Year to date:
  • Site-wide: 148,837
• Since beginning of last month:
  • Site-wide: 165,056

Functional Characterization of a Lassa Virus Fusion Inhibitors Adaptive Mutant

• Downloaded 156 times
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  • Site-wide: 157,458
  • In microbiology: 11,838
• Year to date:
  • Site-wide: 154,948
• Since beginning of last month:
  • Site-wide: 135,121

Association of Visual Impairment with Risk for Future Parkinson's Disease

• Downloaded 156 times
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  • Site-wide: 157,499
  • In epidemiology: 6,545
• Year to date:
  • Site-wide: 154,605
• Since beginning of last month:
  • Site-wide: 169,758

Epidemiological and Clinical Features, Treatment Status, and Economic Burden of Traumatic Spinal Cord Injury in China

• Downloaded 152 times
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  • Site-wide: 158,146
  • In epidemiology: 6,573
• Year to date:
  • Site-wide: 29,295
• Since beginning of last month:
  • Site-wide: 49,719

Screening of Botanical Drugs Against Lassa Virus Entry

• Downloaded 129 times
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  • Site-wide: 162,445
  • In microbiology: 12,315
• Year to date:
  • Site-wide: 146,926
• Since beginning of last month:
  • Site-wide: 166,159

Effects of N-linked glycan of Lassa Virus Envelope Glycoprotein on the Immune Response

• Downloaded 129 times
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  • Site-wide: 162,437
  • In microbiology: 12,305
• Year to date:
  • Site-wide: None
• Since beginning of last month:
  • Site-wide: 169,291

Screening and Identification of Lassa Virus Endonuclease-targeting Inhibitors from a Fragment-based Drug Development Library

• Downloaded 122 times
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  • Site-wide: 163,471
  • In microbiology: 12,428
• Year to date:
  • Site-wide: 123,454
• Since beginning of last month:
  • Site-wide: 18,006

Identification of residues in Lassa virus glycoprotein 1 involved in receptor switch

• Downloaded 120 times
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  • Site-wide: 163,811
  • In microbiology: 12,462
• Year to date:
  • Site-wide: 91,985
• Since beginning of last month:
  • Site-wide: 88,608

Identification of biomarkers and candidate inhibitors for multiple myeloma

• Downloaded 120 times
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  • Site-wide: 163,759
  • In bioinformatics: 12,304
• Year to date:
  • Site-wide: 125,263
• Since beginning of last month:
  • Site-wide: 108,759

Screening and Identification of Lujo Virus Entry Inhibitors from an FDA-Approved Drugs Library

• Downloaded 69 times
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  • Site-wide: 169,865
  • In microbiology: 13,016
• Year to date:
  • Site-wide: 69,737
• Since beginning of last month:
  • Site-wide: 56,003

Young APPKI NL-G-F/NL-G-F mice display high-fat diet-induced metabolic disturbances and specific disorders associated with brain energy homeostasis.

• Downloaded 66 times
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  • Site-wide: 170,049
  • In neuroscience: 25,135
• Year to date:
  • Site-wide: 6,615
• Since beginning of last month:
  • Site-wide: 17,673

Mechanism through which retrocyclin targets flavivirus multiplication

• Downloaded 65 times
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  • Site-wide: 170,151
  • In microbiology: 13,054
• Year to date:
  • Site-wide: 95,015
• Since beginning of last month:
  • Site-wide: 169,874