Author: Gerome Breen

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Preprints

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

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  • Site-wide: 821
  • In genetics: 25
• Year to date:
  • Site-wide: 24,155
• Since beginning of last month:
  • Site-wide: 27,279

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

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  • Site-wide: 1,796
  • In genetics: 68
• Year to date:
  • Site-wide: 27,245
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  • Site-wide: None

Genome wide meta-analysis identifies genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders.

• Downloaded 4,718 times
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  • Site-wide: 2,027
  • In genomics: 215
• Year to date:
  • Site-wide: 10,925
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  • Site-wide: 10,200

A reference panel of 64,976 haplotypes for genotype imputation

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  • Site-wide: 2,114
  • In genetics: 80
• Year to date:
  • Site-wide: 57,920
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  • Site-wide: 53,970

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s Disease

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  • Site-wide: 2,459
  • In genomics: 285
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  • Site-wide: 8,867
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  • Site-wide: 7,400

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

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  • Site-wide: 3,014
  • In genomics: 353
• Year to date:
  • Site-wide: 71,371
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  • Site-wide: 63,299

Exome sequencing identifies rare coding variants in 10 genes which confer substantial risk for schizophrenia

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  • Site-wide: 4,121
  • In genetic and genomic medicine: 11
• Year to date:
  • Site-wide: 993
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  • Site-wide: 1,101

Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traits

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  • Site-wide: 6,176
  • In genetics: 304
• Year to date:
  • Site-wide: 7,398
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  • Site-wide: 6,284

The genetics of the mood disorder spectrum: genome-wide association analyses of over 185,000 cases and 439,000 controls

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  • Site-wide: 6,909
  • In genomics: 777
• Year to date:
  • Site-wide: 33,377
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  • Site-wide: 30,293

Applying polygenic risk scoring for psychiatric disorders to a large family with Bipolar Disorder and Major Depressive Disorder

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  • Site-wide: 8,655
  • In genetics: 423
• Year to date:
  • Site-wide: 62,010
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  • Site-wide: None

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

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  • Site-wide: 9,255
  • In genetics: 457
• Year to date:
  • Site-wide: 16,898
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  • Site-wide: 15,248

Genome-wide association study of over 40,000 bipolar disorder cases provides novel biological insights

• Downloaded 1,557 times
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  • Site-wide: 10,182
  • In psychiatry and clinical psychology: 32
• Year to date:
  • Site-wide: 2,823
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  • Site-wide: 3,652

Genomic dissection of bipolar disorder and schizophrenia including 28 subphenotypes

• Downloaded 1,447 times
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  • Site-wide: 11,333
  • In genomics: 1,260
• Year to date:
  • Site-wide: 61,962
• Since beginning of last month:
  • Site-wide: 63,520

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

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  • Site-wide: 16,552
  • In genetics: 835
• Year to date:
  • Site-wide: 65,461
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  • Site-wide: 55,811

Rare loss-of-function variants in KMT2F are associated with schizophrenia and developmental disorders

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  • Site-wide: 19,343
  • In genomics: 1,982
• Year to date:
  • Site-wide: 76,518
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  • Site-wide: 76,382

Examination of the Shared Genetic Basis of Anorexia Nervosa and Obsessive-Compulsive Disorder

• Downloaded 952 times
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  • Site-wide: 21,184
  • In genetics: 1,042
• Year to date:
  • Site-wide: 75,684
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  • Site-wide: 54,263

FORGE: multivariate calculation of gene-wide p-values from Genome-Wide Association Studies Authors and Affiliations

• Downloaded 867 times
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  • Site-wide: 24,245
  • In genetics: 1,204
• Year to date:
  • Site-wide: 23,653
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  • Site-wide: 13,444

Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores

• Downloaded 835 times
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  • Site-wide: 25,556
  • In genetics: 1,263
• Year to date:
  • Site-wide: 58,504
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  • Site-wide: 44,180

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

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  • Site-wide: 33,383
  • In genetics: 1,650
• Year to date:
  • Site-wide: 18,935
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  • Site-wide: 27,805

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

• Downloaded 633 times
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  • Site-wide: 37,304
  • In genetics: 1,816
• Year to date:
  • Site-wide: 15,442
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  • Site-wide: 6,776

Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia.

• Downloaded 633 times
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  • Site-wide: 37,270
  • In genomics: 3,206
• Year to date:
  • Site-wide: 23,331
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  • Site-wide: 17,898

Evaluation of Polygenic Prediction Methodology within a Reference-Standardized Framework

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  • Site-wide: 39,500
  • In genomics: 3,327
• Year to date:
  • Site-wide: 3,319
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  • Site-wide: 1,325

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

• Downloaded 585 times
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  • Site-wide: 41,191
  • In genomics: 3,425
• Year to date:
  • Site-wide: 110,586
• Since beginning of last month:
  • Site-wide: 96,184

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies

• Downloaded 519 times
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  • Site-wide: 47,688
  • In genetics: 2,275
• Year to date:
  • Site-wide: 93,861
• Since beginning of last month:
  • Site-wide: 75,715

Genetic effects on educational attainment in Hungary

• Downloaded 462 times
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  • Site-wide: 54,426
  • In genetics: 2,578
• Year to date:
  • Site-wide: 40,788
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  • Site-wide: 52,892

Using Major Depression Polygenic Risk Scores to Explore the Depressive Symptom Continuum

• Downloaded 441 times
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  • Site-wide: 57,205
  • In genetics: 2,713
• Year to date:
  • Site-wide: 78,346
• Since beginning of last month:
  • Site-wide: 58,344

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

• Downloaded 414 times
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  • Site-wide: 60,981
  • In genetic and genomic medicine: 183
• Year to date:
  • Site-wide: 10,979
• Since beginning of last month:
  • Site-wide: 17,912

Genomic Influences on Self-Reported Childhood Maltreatment

• Downloaded 373 times
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  • Site-wide: 67,518
  • In genomics: 4,769
• Year to date:
  • Site-wide: 106,756
• Since beginning of last month:
  • Site-wide: 82,590

Predicting Eating Disorder and Anxiety Symptoms Using Anorexia Nervosa and Obsessive-Compulsive Disorder Polygenic Scores

• Downloaded 312 times
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  • Site-wide: 78,336
  • In psychiatry and clinical psychology: 244
• Year to date:
  • Site-wide: 35,387
• Since beginning of last month:
  • Site-wide: 42,454

Imputed Gene Expression Risk Scores: A Functionally Informed Component of Polygenic Risk

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  • Site-wide: 82,442
  • In genomics: 5,357
• Year to date:
  • Site-wide: 12,468
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  • Site-wide: 14,633

Genes associated with neuropsychiatric disease increase vulnerability to abnormal deep grey matter development

• Downloaded 270 times
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  • Site-wide: 87,045
  • In neuroscience: 13,566
• Year to date:
  • Site-wide: 114,839
• Since beginning of last month:
  • Site-wide: 81,728