Author: Alanna C. Morrison

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Preprints

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

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  • Site-wide: 2,629
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Genetic analysis of over one million people identifies 535 novel loci for blood pressure.

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  • Site-wide: 3,553
  • In genetics: 163
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  • Site-wide: 18,924
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Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestries

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  • Site-wide: 8,921
  • In genetics: 454
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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

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  • Site-wide: 10,511
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• Year to date:
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Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

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  • Site-wide: 14,728
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Efficient variant set mixed model association tests for continuous and binary traits in large-scale whole genome sequencing studies

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  • In genetics: 1,234
• Year to date:
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Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure

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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

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  • Site-wide: 29,031
  • In genetic and genomic medicine: 73
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ACAT: A Fast and Powerful P-value Combination Method for Rare-variant Analysis in Sequencing Studies

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  • In genetics: 1,533
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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

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  • Site-wide: 33,685
  • In genomics: 2,986
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  • Site-wide: 50,871

Multiethnic Meta-analysis Identifies New Loci for Pulmonary Function

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  • In genetics: 1,895
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  • Site-wide: 114,636
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  • Site-wide: 113,820

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

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  • Site-wide: 47,378
  • In genomics: 3,801
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  • Site-wide: 84,017
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  • Site-wide: 114,921

Meta-analysis of exome array data identifies six novel genetic loci for lung function

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  • Site-wide: 50,708
  • In genetics: 2,460
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  • Site-wide: 60,413
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  • Site-wide: 113,282

Rare coding variants in 35 genes associate with circulating lipid levels: a multi-ancestry analysis of 170,000 exomes

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  • Site-wide: 51,523
  • In genetics: 2,496
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GEM: Scalable and flexible gene-environment interaction analysis in millions of samples

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  • In bioinformatics: 5,770
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Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole Genome Sequencing Studies

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  • Site-wide: 65,507
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Impact of rare and common genetic variants on diabetes diagnosis by hemoglobin A1c in multi-ancestry cohorts: The Trans-Omics for Precision Medicine Program.

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  • Site-wide: 65,502
  • In genetics: 3,117
• Year to date:
  • Site-wide: 53,235
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  • Site-wide: 119,627

Role of Rare and Low Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

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  • Site-wide: 81,249
  • In epidemiology: 3,282
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  • Site-wide: 59,252
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  • Site-wide: 109,539

A system for phenotype harmonization in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 84,749
  • In genetics: 3,939
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Evaluation of the causal effect of fibrinogen on incident coronary heart disease via Mendelian randomization

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  • In genetics: 3,945
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Efficient gene-environment interaction tests for large biobank-scale sequencing studies

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  • Site-wide: 85,823
  • In genetics: 3,988
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  • Site-wide: 45,464
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  • Site-wide: 75,627

Whole genome sequencing association analysis of quantitative red blood cell phenotypes: the NHLBI TOPMed program

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  • Site-wide: 89,332
  • In hematology: 50
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Rare Non-coding Variation Identified by Large Scale Whole Genome Sequencing Reveals Unexplained Heritability of Type 2 Diabetes: Trans-Omics for Precision Medicine (TOPMed) Program

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  • Site-wide: 92,792
  • In genetic and genomic medicine: 305
• Year to date:
  • Site-wide: 38,947
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  • Site-wide: 8,978

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

• Downloaded 193 times
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  • Site-wide: 98,880
  • In genomics: 5,914
• Year to date:
  • Site-wide: 81,870
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  • Site-wide: 75,573

Lifestyle Risk Score for aggregating multiple lifestyle factors: Handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions

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  • Site-wide: 116,437
  • In genetics: 5,086
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  • Site-wide: 88,590

Whole Genome Sequence Association Analysis of Fasting Glucose and Fasting Insulin Levels in Diverse Cohorts from the NHLBI TOPMed Program

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  • Site-wide: 119,295
  • In genetic and genomic medicine: 516
• Year to date:
  • Site-wide: 2,235
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BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

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  • Site-wide: 123,208
  • In genetic and genomic medicine: 543
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